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  1. Article

    Open Access

    The combination of nano-calcium sulfate/platelet rich plasma gel scaffold with BMP2 gene-modified mesenchymal stem cells promotes bone regeneration in rat critical-sized calvarial defects

    Mesenchymal stem cells (MSCs) can be differentiated into an osteoblastic lineage in the presence of growth factors (GFs). Platelet-rich plasma (PRP), which can be easily isolated from whole blood, contains a l...

    Zunpeng Liu, Xue Yuan, Gabriela Fernandes, Rosemary Dziak… in Stem Cell Research & Therapy (2017)

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    Article

    Regulation of C-myc protooncogene expression in osteoblastic cells by arachidonic acid metabolites: Relationship to proliferation

    Prostaglandin E2 and leukotriene B4 are metabolites of arachidonic acid with well-characterized effects on osteoblastic cells. Prostaglandin E2 has been shown to be a potent bone-resorbing agent and to stimulate ...

    Wei Ren, Alan J. Kinniburgh, Rosemary Dziak in Calcified Tissue International (1992)

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    Article

    Effects of inositol trisphosphate on calcium mobilization in bone cells

    The effect of inositol 1,4,5 trisphosphate (IP3) on calcium mobilization was studied in human osteosarcoma lines, Saos-2 and G292, as well as isolated rat osteoblastic and osteoclastic cells. Cells were permeabil...

    Rebecca Falsafi, Dimitris N. Tatakis, Susan Hagel-Bradway… in Calcified Tissue International (1991)

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    Article

    Effects of leukotrienes on osteoblastic cell proliferation

    Leukeotriene B4 (LTB4) is an arachidonic acid lipoxygenase metabolite with well-characterized effects on leukocytes. LTB4 has been implicated in acute inflammatory reactions and in bone resorption. In the present...

    Wei Ren, Rosemary Dziak in Calcified Tissue International (1991)

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    Article

    Recombinant interleukin-1 stimulates prostaglandin E2 production by osteoblastic cells: Synergy with parathyroid hormone

    Recombinant mouse IL-1 (Interleukin-1) has been shown to be capable of stimulating prostaglandin E2 (PGE2) production by isolated rat osteoblastic cells in a dose-dependent manner. The rapidity of the effect (1 h...

    Dr. Dimitris N. Tatakis, Gerald Schneeberger… in Calcified Tissue International (1988)

  6. No Access

    Chapter

    Prostaglandins as Mediators of Bone Cell Metabolism

    Prostaglandins are unsaturated, hydroxylated, 20-carbon fatty acids consisting of a five- membered ring and two aliphatic side chains. They are formed from essential polyunsaturated fatty acids and appear to b...

    Rosemary Dziak in Calcium in Biological Systems (1985)

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    Article

    Effects of vitamin D3 metabolites on bone cell calcium transport

    The vitamin D3 metabolite, 25-hydroxycholecalciferol, at concentrations of 0.01 to 10.0 μg/ml, decreased calcium uptake by isolated bone cells. The effect occurred within 1 min after the simultaneous addition of ...

    Rosemary Dziak in Calcified Tissue Research (1978)