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Article
Open AccessEpigenetic origin of evolutionary novel centromeres
Most evolutionary new centromeres (ENC) are composed of large arrays of satellite DNA and surrounded by segmental duplications. However, the hypothesis is that ENCs are seeded in an anonymous sequence and only...
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Protocol
Fluorescence In Situ Hybridization Probe Preparation
The public human genome sequencing project utilized a hierarchical approach. A large number of BAC/PAC clones, with an insert size approximate from 50 kb to 300 kb, were identified and finely mapped with respe...