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β-Lactams Through Single Bond Ring Closing: Methods, Transformations and Bioactivity

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  1. Article

    Open Access

    Highly functionalized β-lactams and 2-ketopiperazines as TRPM8 antagonists with antiallodynic activity

    The cool sensor transient receptor potential melastatin channel 8 (TRPM8) is highly expressed in trigeminal and dorsal root ganglia, playing a key role in cold hypersensitivity associated to different peripher...

    M.Ángeles Bonache, Cristina Martín-Escura… in Scientific Reports (2020)

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  2. Article

    Open Access

    Synthesis, high-throughput screening and pharmacological characterization of β–lactam derivatives as TRPM8 antagonists

    The mammalian transient receptor potential melastatin channel 8 (TRPM8), highly expressed in trigeminal and dorsal root ganglia, mediates the cooling sensation and plays an important role in the cold hypersens...

    Roberto de la Torre-Martínez, M. Angeles Bonache… in Scientific Reports (2017)

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