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Article
2-Alkyl-2-carboxyazetidines as γ-turn inducers: incorporation into neurotrophin fragments
Conveniently substituted 2-alkyl-2-carboxyazetidine amino acids have been incorporated into NGF and NT3 tetrapeptide sequences to investigate their utility as reverse turn inducers (γ- vs. β-turns). Despite th...
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Article
Exploring solid-phase approaches for the preparation of new β-lactams from amino acids
Two solid-phase approaches, involving the base-assisted intramolecularalkylation of N-chloroacetyl-Phe derivatives anchored to appropriatesolid supports, were investigated for the preparation of novel β-lactams. ...
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Chapter
PACAP27 Analogues Incorporating Type II/II’ β-Turn Mimetics
Pituitary adenyl cyclase-activating peptide (PACAP) is a member of the superfamily of regulatory peptides including secretin, glucagon, VIP and GRF [1]. It exists in two bioactive forms, PACAP38 and its shorte...
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Article
Studies on the synthesis of β-keto esters derived from dipeptides: search for a low-epimerizing method
β-Keto esters derived from dipeptides areprepared by application of common methodologiesemployed for the synthesis of amino acid-derivedβ-keto esters; however, epimerization of theC-terminal residue occurred t...
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Article
Constrained C-terminal hexapeptide neurotensin analogues containing a 3-oxoindolizidine skeleton
In order to enforce different spatial orientations in the C-terminal hexapeptide of neurotensin (NT8−13) and to gain information about the importance of the 10–11 peptide bond for binding to NT receptors, the Pro