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  1. No Access

    Chapter

    Maternal Metabolic State and Cancer Risk: An Evolving Manifestation of Generational Impact

    Metabolic stress in the early-life environment as a consequence of maternal overnutrition and obesity leads to an increased risk of adult metabolic syndrome in offspring. Given the greater risk for cancer deve...

    Frank A. Simmen PhD, Melissa E. Heard… in Parental Obesity: Intergenerational Progra… (2016)

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    Chapter and Conference Paper

    IGF System in Periimplantation Uterus and Embryonic Development

    The periimplantation period represents a critical point in pregnancy when biological interactions between the embryo and the maternal uterus must be coordinated to ensure a suitable environment for implantatio...

    Rosalia C. M. Simmen, Michael L. Green… in Molecular and Cellular Aspects of Periimpl… (1995)

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    Chapter

    IGFs in Pregnancy: Developmental Expression in Uterus and Mammary Gland and Paracrine Actions during Embryonic and Neonatal Growth

    The insulin-like growth factors (IGF-I, IGF-II) are structural homologs of insulin that are mitogenic in vivo and in vitro 1. These peptides are also characterized by other actions which include the...

    Frank A. Simmen, Rosalia C. M. Simmen… in Molecular and Cellular Biology of Insulin-… (1989)