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Article
Influence of cognition on the correlation between objective and subjective upper limb measures in people with multiple sclerosis
A comprehensive assessment of upper limb (UL) function is mandatory in people with multiple sclerosis (PwMS), and the use of multiple objective and subjective measures is advisable. Findings on the role of cog...
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Article
Cross-cultural validity and reliability of the comprehensive assessment of acceptance and commitment therapy processes (CompACT) in people with multiple sclerosis
The Comprehensive assessment of Acceptance and Commitment Therapy (CompACT) is a 23-item questionnaire measuring psychological flexibility, a quality of life protective factor. An 18-item version was recently ...
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Article
Open AccessApplying multidimensional computerized adaptive testing to the MSQOL-54: a simulation study
The Multiple Sclerosis Quality of Life-54 (MSQOL-54) is one of the most commonly-used MS-specific health-related quality of life (HRQOL) measures. It is a multidimensional, MS-specific HRQOL inventory, which i...
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Article
Open AccessViability of a MSQOL-54 general health-related quality of life score using bifactor model
MSQOL-54 is a multidimensional, widely-used, health-related quality of life (HRQOL) instrument specific for multiple sclerosis (MS). Findings from the validation study suggested that the two MSQOL-54 composite...
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Article
Open AccessResponse shift in health-related quality of life measures in the presence of formative indicators
Response shift (RS) has been defined as a change in the meaning of an individual’s self-evaluation that needs to be accounted for when assessing longitudinal changes in health-related quality of life (HRQoL). ...
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Article
Acute assessment of subjective appetite and implicated hormones after a hypnosis-induced hallucinated meal: a randomized cross-over pilot trial
The use of hypnosis can generate hallucinatory phenomena, which ranged from vivid/auditory imagery to fully developed “hallucinations” in selected people. The aim of this pilot trial was investigating the acut...
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Article
Italian translation and psychometric validation of the Manual Ability Measure-36 (MAM-36) and its correlation with an objective measure of upper limb function in patients with multiple sclerosis
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system with an unpredictable course. During its course, deficits affecting upper limb functions may occur. Hence, there is a need ...
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Article
Open AccessIs HDL cholesterol protective in patients with type 2 diabetes? A retrospective population-based cohort study
The protective role of high HDL cholesterol levels against cardiovascular diseases has been recently questioned. Limited data are available on this specific topic in patients with type 2 diabetes mellitus (T2D...
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Article
Assessing measurement invariance of MSQOL-54 across Italian and English versions
The Multiple Sclerosis Quality of Life-54 (MSQOL-54) is a specific multiple sclerosis (MS) health-related quality of life inventory consisting of 52 items organized into 12 subscales plus two single items. No ...
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Article
Open AccessChanges in the gut microbiota composition during pregnancy in patients with gestational diabetes mellitus (GDM)
Gestational diabetes mellitus (GDM), a common pregnancy complication, is associated with an increased risk of maternal/perinatal outcomes. We performed a prospective observational explorative study in 41 GDM p...
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Article
Open AccessImpact of sirtuin-1 expression on H3K56 acetylation and oxidative stress: a double-blind randomized controlled trial with resveratrol supplementation
Sirtuin-1 (SIRT-1) down-regulation in type 2 diabetes mellitus (T2DM) has been associated with epigenetic markers of oxidative stress. We herein aim to evaluate whether an increase in SIRT-1 expression affects...
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Article
Open AccessMultivariate projection method to investigate inflammation associated with secondary insults and outcome after human traumatic brain injury: a pilot study
Neuroinflammation has been proposed as a possible mechanism of brain damage after traumatic brain injury (TBI), but no consensus has been reached on the most relevant molecules. Furthermore, secondary insults ...
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Article
Quality of life and patient preferences: identification of subgroups of multiple sclerosis patients
The aim of this study was to estimate preferences related to quality of life attributes in people with multiple sclerosis, by kee** heterogeneity of patient preference in mind, using the latent class approach.
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Article
Open AccessHospital factors and patient characteristics in the treatment of colorectal cancer: a population based study
The present study focuses on the analysis of social, clinical and hospital characteristics that can lead to disparities in the management and outcome of care. To that end, indicators of the quality of initial ...
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Article
Nonopioid placebo analgesia is mediated by CB1 cannabinoid receptors
The placebo response involves a perceived effect of a drug that was not really received by the subject. Fabrizio Benedetti and colleagues demonstrate that the placebo response to NSAIDs in reducing pain is med...
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Article
Using Data Mining Techniques in Monitoring Diabetes Care. The Simpler the Better?
We aim at evaluating how data-mining statistical techniques can be applied on medical records and administrative data of diabetes and how they differ in terms of capabilities of predicting outcomes (e.g. death...
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Article
Open AccessDiffusion of good practices of care and decline of the association with case volume: the example of breast conserving surgery
Several previous studies conducted on cancer registry data and hospital discharge records (HDR) have found an association between hospital volume and the recourse to breast conserving surgery (BCS) for breast ...
