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    Article

    Acetyl-11-keto-β-boswellic acid suppresses docetaxel-resistant prostate cancer cells in vitro and in vivo by blocking Akt and Stat3 signaling, thus suppressing chemoresistant stem cell-like properties

    Acquired docetaxel-resistance of prostate cancer (PCa) remains a clinical obstacle due to the lack of effective therapies. Acetyl-11-keto-β-boswellic acid (AKBA) is a pentacyclic triterpenic acid isolated from...

    Yong-qing Liu, Shi-kang Wang, Qing-qing Xu, Hui-qing Yuan… in Acta Pharmacologica Sinica (2019)

  2. Article

    LY333531, a PKCβ inhibitor, attenuates glomerular endothelial cell apoptosis in the early stage of mouse diabetic nephropathy via down-regulating swiprosin-1

    Glomerular endothelial cell (GEC) injury plays an important role in the early stage of diabetic nephropathy (DN). Previous studies show that a PKCβ inhibitor is effective for treating DN. In the current study ...

    Zhi-bin Wang, Su Zhang, Ya Li, Rong-mei Wang, Ling-chang Tong… in Acta Pharmacologica Sinica (2017)

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