12 Result(s)

Article

Practical example of multiple antibody screening for evaluation of malaria control strategies

Ongoing efforts to fight Plasmodium falciparum malaria has reduced malaria in many areas, but new tools are needed to monitor further progress, including indicators of decreasing exposure to parasite infection. S...

Marie-Louise Varela, David Koffi, Michael White, Makhtar Niang… in Malaria Journal (2020)

Article

Association of high Plasmodium falciparum parasite densities with polyclonal microscopic infections in asymptomatic children from Toubacouta, Senegal

Malaria is a leading cause of mortality and morbidity in tropical countries, especially in sub-Saharan Africa. In Senegal, a control plan implemented in the beginning of the 2000s has enabled a substantial red...

Babacar Diouf, Fode Diop, Yakhya Dieye, Cheikh Loucoubar, Ibrahima Dia… in Malaria Journal (2019)

Article

Optimization of a magnetic bead-based assay (MAGPIX^®-Luminex) for immune surveillance of exposure to malaria using multiple Plasmodium antigens and sera from different endemic settings

Serological markers are potentially useful tools for monitoring the progress of malaria control programs, but a better understanding of antibody response dynamics is necessary. The use of a magnetic bead-based...

Marie Louise Varela, Babacar Mbengue, Aissata Basse, Cheikh Loucoubar… in Malaria Journal (2018)

Article

Unexpected high circulation of Plasmodium vivax in asymptomatic children from Kédougou, southeastern Senegal

Malaria in Senegal is due essentially to infections by Plasmodium falciparum and, to a lesser extent to Plasmodium malariae and Plasmodium ovale. By the use of molecular methods, detection of Plasmodium vivax has...

Makhtar Niang, Fode Diop, Oulimata Niang, Bacary D. Sadio… in Malaria Journal (2017)

Article

Modelling dynamic change of malaria transmission in holoendemic setting (Dielmo, Senegal) using longitudinal measures of antibody prevalence to Plasmodium falciparum crude schizonts extract

Evaluation of local Plasmodium falciparum malaria transmission has been investigated previously using the reversible catalytic model based on prevalence of antibody responses to single antigen to estimate serocon...

Oumy Niass, Philippe Saint-Pierre, Makhtar Niang, Fode Diop… in Malaria Journal (2017)

Article

Temporal analysis of IgG antibody responses to Plasmodium falciparum antigens in relation to changing malaria epidemiology in a West African setting

Coordinated scaled-up malaria control interventions have substantially contributed to the dramatic decrease of malaria-related morbidity and mortality in several endemic countries, including Senegal. However, ...

Makhtar Niang, Oumy Niass, Nafissatou Diagne, Fatoumata Diene Sarr… in Malaria Journal (2017)

Article

Analysis of antibody profiles in symptomatic malaria in three sentinel sites of Ivory Coast by using multiplex, fluorescent, magnetic, bead-based serological assay (MAGPIX™)

Advances in malaria control have reduced the burden of disease resulting from exposure to parasite infections. The consequences on naturally acquired immunity are unclear. A magnetic bead-based immunoassay (MB...

David Koffi, André Offianan Touré, Marie-Louise Varela, Inès Vigan-Womas… in Malaria Journal (2015)

Article

Antibodies to Plasmodium falciparum merozoite surface protein-1p19 malaria vaccine candidate induce antibody-dependent respiratory burst in human neutrophils

Identification of plasmodial antigens targeted by protective immune mechanisms is important for malaria vaccine development. Among functional assays, the neutrophil antibody-dependent respiratory burst (ADRB) ...

Charlotte Joos, Marie-Louise Varela, Babacar Mbengue, Annick Mansourou… in Malaria Journal (2015)

Article

A molecular survey of acute febrile illnesses reveals Plasmodium vivax infections in Kedougou, southeastern Senegal

Control efforts towards malaria due to Plasmodium falciparum significantly decreased the incidence of the disease in many endemic countries including Senegal. Surprisingly, in Kedougou (southeastern Senegal) P. f...

Makhtar Niang, Laty Gaye Thiam, Abdourahmane Sow, Cheikh Loucoubar… in Malaria Journal (2015)

Article

Comparative analysis of IgG responses to Plasmodium falciparum MSP1p19 and PF13-DBL1α1 using ELISA and a magnetic bead-based duplex assay (MAGPIX®-Luminex) in a Senegalese meso-endemic community

Numerous Plasmodium falciparum antigens elicit humoral responses in humans living in endemic areas. Use of multiplex assays is a convenient approach to monitor the antibody response against multiple antigens, but...

Ronald Perraut, Vincent Richard, Marie-Louise Varela… in Malaria Journal (2014)

Article

Assessment of the relative success of sporozoite inoculations in individuals exposed to moderate seasonal transmission

The time necessary for malaria parasite to re-appear in the blood following treatment (re-infection time) is an indirect method for evaluating the immune defences operating against pre-erythrocytic and early e...

Adama Tall, Cheikh Sokhna, Ronald Perraut, Didier Fontenille… in Malaria Journal (2009)

Article

Differential kinetics of plasma procalcitonin levels in cerebral malaria in urban Senegalese patients according to disease outcome

Babacar Mbengue, Bacary Diatta, Birahim Niang, Ngor Diagne… in BMC Proceedings (2008)