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Article
Tracking donor RBC survival in premature infants: agreement of multiple populations of biotin-labeled RBCs with Kidd antigen–mismatched RBCs
Anemia, a common condition among critically ill premature infants, is affected by red blood cell (RBC) survival (RCS). We hypothesized that transfused allogeneic Kidd antigen–mismatched RBCs would demonstrate ...
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Article
Comparison of multiple red cell volume methods performed concurrently in premature infants following allogeneic transfusion
Study of the pathophysiology and treatment of anemia of prematurity is facilitated by direct measurement of red cell volume (RCV) utilizing microliter quantities of blood samples. Our objective was to compare ...
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Article
Red Cell Volume Can Be Accurately Determined in Sheep Using a Nonradioactive Biotin Label
The sheep has served as an informative animal model for investigation of human fetal and newborn erythropoiesis and red blood cell (RBC) kinetics. We previously validated the permanent label (14C)cyanate for meas...
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Article
Circulating Red Cell Volume and Red Cell Survival Can Be Accurately Determined in Sheep Using the [14C]Cyanate Label
The sheep commonly serves as an animal model for investigation of human fetal and newborn erythropoiesis and red blood cell kinetics. Measurement of red cell volume (RCV) and survival (RCS) in sheep would be u...
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Article
[14C]Cyanate Labeling of Sheep Red Cells: Covalent Binding to Hemoglobin Continues in Vivo for a Day
The sheep is a useful model to study fetal and newborn physiology including perinatal erythropoiesis and red cell kinetics. A practical, economical method for measuring red cell survival (RCS) in sheep would b...
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Article
CHANGING PATTERNS OF RED BLOOD CELL TRANSFUSION IN VERY LOW BIRTHWEIGHT INFANTS. † 1500
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Article
1537 UNIT DOSE, READY-TO-USE BLOOD PRODUCTS FOR NEONATES
A system was designed to dispense precise volumes of prefiltered, sterile, quality blood for immediate infusion into designated infants without waste. In the blood bank, the volume ordered was aspirated from t...
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Article
UPTAKE OF RADIOACTIVE CALCIUM (45Ca) BY NEUTROPHILS (PMN) FROM HUMAN NEONATES
Abnormal chemotaxis, deformability, and lectin cap** of neonatal PMN may be due to abnormal plasma membrane structure or function (eg, altered Ca uptake after pertubation). We studied 45Ca uptake by blood PMN f...
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Article
Activation and Activity of the Superoxide-Generating System of Neutophils from Human Infants
Summary: We investigated the superoxide-generating system of neutrophils obtained from human neonates and their mothers. Using a standard assay to measure the cumulative production of superoxide anion over 15 ...
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Chapter
The Role of Therapeutic and Prophylactic Granulocyte Transfusions in Adult Acute Leukemia
Great strides have been made in the induction phase of treatment for acute leukemia. Although the majority of patients will achieve an initial remission, varying periods of pancytopenia are experienced by virt...
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Article
Spontaneous and Drug-Induced Concanavalin A Cap** of Neutrophils from Human Infants and Their Mothers
Summary: We investigated concanavalin A cap** that occurred either spontaneously (neutrophils incubated only with buffer) or was drug induced (neutrophils with colchicine or diamide) using neutrophils obtain...
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Article
880 AUTOOXIDATION AND DECREASED VIABILITY OF NEUTROPHILS OBTAINED FROM HUMAN INFANTS
Infant neutrophils (N) exhibit decreased viability in vitro. We investigated autooxidation as a cause since increased oxidative metabolism and decreased oxidant protective enzymes (glutathione peroxidase and c...
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Article
879 ABNORMAL CONCANAVALIN A CAPPING – ANOTHER DEFECT OF NEUTROPHILS FROM HUMAN INFANTS
Concanavalin A (con A) binds to neutrophil (N) plasma membranes and induces granule exocytosis, chemotaxis and increased oxidative metabolism. Con A binds diffusely to the N surface, but caps form on N exposed...
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Chapter
Formed Elements of Human Blood
The formed elements present in the blood of the human fetus and newborn differ in many respects from those found in older children and adults. Differences have been reported in the metabolism, functions, and c...
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Article
OXIDATIVE METABOLISM IN HUMAN CORD BLOOD NEUTROPHILS
Oxidative metabolism (OxM) was assessed in cord blood, neutrophils (CBN) in an attempt to explain the susceptibility of infants to infections. A variety of methods were employed in prior reports, and results h...
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Article
Alternative Pathway of Complement in Sickle Cell Disease
Summary: Thirty-one patients, 10 months to 20 years of age, were studied. A complement abnormality was not identified in sera from patients with sickle cell disease (SCD) by the methods employed in the present...
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Article
VARICELLA-ZOSTER VIREMIA: ASSOCIATION WITH PROGRESSIVE VARICELLA
In retrospect, progressive varicella (the clinical involvement of organ systems other than the skin, the prolonged appearance of vesicles, or clinically significant hemorrhage) is usually not difficult to dist...