51 Result(s)
within
Rolf-Dieter Kortmann
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Article
Open AccessPineal anlage tumor: clinical and diagnostic features, and rationales for treatment
To provide a treatment-focused review and develop basic treatment guidelines for patients diagnosed with pineal anlage tumor (PAT).
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Article
Open AccessGenetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas
This study aimed to re-evaluate the prognostic impact of TP53 mutations and to identify specific chromosomal aberrations as possible prognostic markers in WNT-activated medulloblastoma (WNT-MB). In a cohort of 19...
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Article
Open AccessClinical and molecular characterization of isolated M1 disease in pediatric medulloblastoma: experience from the German HIT-MED studies
To evaluate the clinical impact of isolated spread of medulloblastoma cells into cerebrospinal fluid without additional macroscopic metastases (M1-only).
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Article
Open AccessSystemic chemotherapy of pediatric recurrent ependymomas: results from the German HIT-REZ studies
Survival in recurrent ependymoma (EPN) depends mainly on the extent of resection achieved. When complete resection is not feasible, chemotherapy is often used to extend progression-free and overall survival. H...
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Article
Open AccessEvaluation of treatment-associated eye toxicity after irradiation in childhood and adolescence—results from the Registry of the Evaluation of Side Effects after Radiotherapy in Childhood and Adolescence (RiSK)
The aim of the study is to evaluate treatment-related acute and late eye toxicity associated with radiation therapy in childhood and adolescence as correlated with RT (radiotherapy) doses.
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Living Reference Work Entry In depth
Hirntumoren
Im Kindesalter ist das Gehirn die häufigste Lokalisation solider Tumoren. Etwa die Hälfte der Fälle der Betroffenen hat ein Astrozytom niedriggradiger Malignität, das somit die häufigste von vielen, teils neu ...
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Article
Open AccessCDKN2A deletion in supratentorial ependymoma with RELA alteration indicates a dismal prognosis: a retrospective analysis of the HIT ependymoma trial cohort
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Living Reference Work Entry In depth
Radiation Therapy in Ependymal Tumors
Ependymoma are rare malignant CNS tumors of the WHO grades I–III in children and adults with a tendency to spread within in the CSF. Several genetic subtypes with different clinical behaviors have been discove...
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Article
Open AccessImproved risk-stratification for posterior fossa ependymoma of childhood considering clinical, histological and genetic features – a retrospective analysis of the HIT ependymoma trial cohort
Risk stratification of children with ependymomas of the posterior fossa in current therapeutic protocols is mainly based on clinical criteria. We aimed to identify independent outcome predictors for this disea...
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Article
Structured multi-disciplinary psychosocial care for cancer patients and the perceived quality of care from the patient perspective: a cluster-randomized trial
We examined whether multi-disciplinary stepped psychosocial care for cancer patients improves quality of care from the patient perspective.
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Article
Open AccessThe Chk1 inhibitor SAR-020106 sensitizes human glioblastoma cells to irradiation, to temozolomide, and to decitabine treatment
Glioblastoma is the most common and aggressive brain tumour in adults with a median overall survival of only 14 months after standard therapy with radiation therapy (IR) and temozolomide (TMZ). In a novel mult...
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Article
Assembling the brain trust: the multidisciplinary imperative in neuro-oncology
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Article
Tumor growth patterns of MGMT-non-methylated glioblastoma in the randomized GLARIUS trial
We evaluated patterns of tumor growth in patients with newly diagnosed MGMT-non-methylated glioblastoma who were assigned to undergo radiotherapy in conjunction with bevacizumab/irinotecan (BEV/IRI) or standar...
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Article
Psychiatric co-morbidity, distress, and use of psycho-social services in adult glioma patients—a prospective study
Distress impacts the daily life of glioma patients. This study explored its course over time and the usage of psychosocial care.
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Living Reference Work Entry In depth
Embryonal Tumors
Embryonal tumors of the central nervous system (CNS) are the most common group of malignant brain tumors in childhood. Diagnosis and classification of these tumors got refined repeatedly over the last decade, ...
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Article
Tropomyosin receptor kinase C (TrkC) expression in medulloblastoma: relation to the molecular subgroups and impact on treatment response
High messenger RNA (mRNA) expression of the tropomyosin receptor kinase C gene (TrkC) has been associated with favorable survival in medulloblastoma patients. Untested is whether it plays a role through modulatin...
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Article
White matter lesions reduce number of brain metastases in different cancers: a high-resolution MRI study
Brain metastases are major complications of common cancers. Tumor type and proneness to the CNS are thought to define the number and size of brain metastases. It is not known if intrinsic vascular factors can ...
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Article
Open AccessEnhanced inhibition of clonogenic survival of human medulloblastoma cells by multimodal treatment with ionizing irradiation, epigenetic modifiers, and differentiation-inducing drugs
Medulloblastoma (MB) is the most common pediatric brain tumor. Current treatment regimes consisting of primary surgery followed by radio- and chemotherapy, achieve 5-year overall survival rates of only about 6...
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Article
Re-irradiation or re-operation followed by dendritic cell vaccination? Comparison of two different salvage strategies for relapsed high-grade gliomas by means of a new prognostic model
We aimed to compare two different salvage treatment strategies for relapsed high-grade glioma (HGG) patients by means of a new prognostic model. A simplified version of the so-called HGG-Immuno RPA model estim...
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Article
Hepatotoxicity after liver irradiation in children and adolescents
The aim of this study was to evaluate acute and late radiotherapy-associated hepatotoxicity in consideration of dose–volume effects and liver function in childhood and adolescence.
