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Article
A biophysically comprehensive model of urothelial afferent neurons: implications for sensory signalling in urinary bladder
The urothelium is the innermost layer of the bladder wall; it plays a pivotal role in bladder sensory transduction by responding to chemical and mechanical stimuli. The urothelium also acts as a physical barri...
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Article
Spontaneous synaptic drive in detrusor smooth muscle: computational investigation and implications for urinary bladder function
The detrusor, a key component of the urinary bladder wall, is a densely innervated syncytial smooth muscle tissue. Random spontaneous release of neurotransmitter at neuromuscular junctions (NMJs) in the detrus...
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Article
A computational model of large conductance voltage and calcium activated potassium channels: implications for calcium dynamics and electrophysiology in detrusor smooth muscle cells
The large conductance voltage and calcium activated potassium (BK) channels play a crucial role in regulating the excitability of detrusor smooth muscle, which lines the wall of the urinary bladder. These chan...
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Chapter and Conference Paper
Modulating Properties of Hyperpolarization-Activated Cation Current in Urinary Bladder Smooth Muscle Excitability: A Simulation Study
Smooth muscle cells from the urinary bladder display enhanced spontaneous electrical activities during the overactive bladder state. It is very well known that the electrical properties of all excitable cells ...
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Chapter and Conference Paper
Modeling Vas Deferens Smooth Muscle Electrophysiology: Role of Ion Channels in Generating Electrical Activity
The vas deferens smooth muscle (VDSM) cells contract to direct and propel sperms from the epididymis to the urethra. It is well known that membrane electrical activity, particularly the action potential (AP) i...
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Article
Effects of location and extent of spine clustering on synaptic integration in striatal medium spiny neurons—a computational study
The nucleus accumbens (NAc) is known widely for its role in the reward circuit, which is dysregulated in a number of psychological disorders. Recent evidence also suggests the contribution of this structure in...
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Article
A computational model of urinary bladder smooth muscle syncytium
Certain smooth muscles, such as the detrusor of the urinary bladder, exhibit a variety of spikes that differ markedly in their amplitudes and time courses. The origin of this diversity is poorly understood but...
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Article
Modulation of synaptic potentials and cell excitability by dendritic KIR and KAs channels in nucleus accumbens medium spiny neurons: A computational study
The nucleus accumbens (NAc), a critical structure of the brain reward circuit, is implicated in normal goal-directed behaviour and learning as well as pathological conditions like schizophrenia and addiction. ...
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Article
Open AccessKIR currents suppress neuronal spiking for unsynchronized distal synaptic inputs in striatal medium spiny neurons: a computational study
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Article
Differences in biophysical properties of nucleus accumbens medium spiny neurons emerging from inactivation of inward rectifying potassium currents
Inward rectifying potassium (KIR) currents in medium spiny (MS) neurons of nucleus accumbens inactivate significantly in ~40% of the neurons but not in the rest, which may lead to differences in input processing ...
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Article
Open AccessKIR current inactivation modulates dendritic calcium in medium spiny neurons
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Article
Open AccessKIR channels in nucleus accumbens MS neurons modulate integration of excitatory synaptic inputs: a computational study
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Article
Open AccessModulation of synaptically induced burst strength and spike onset timing by inactivating KIRcurrents in medium spiny neurons
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Article
Open AccessDifferences in biophysical properties of nucleus accumbens medium spiny neurons emerging from inactivation of inward rectifying potassium currents
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Article
Effects of carbenoxolone on syncytial electrical properties and junction potentials of guinea-pig vas deferens
The effects of the putative gap junction blocker carbenoxolone on smooth muscle syncytial properties and junction potentials were studied in guinea pig vas deferens (GPVD). Treatment with 50 μM carbenoxolone r...
