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Article
Open AccessClinical and Immunological Features of SARS-CoV-2 Breakthrough Infections in Vaccinated Individuals Requiring Hospitalization
Waning immunity and the surge of SARS-CoV-2 variants are responsible for breakthrough infections, i.e., infections in fully vaccinated individuals. Although the majority of vaccinated infected subjects report ...
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Protocol
TCR Vβ Evaluation by Flow Cytometry
T-cell receptor (TCR)-Vβ repertoire analysis is a sensitive method for detection of T-cell clonality. This type of analysis has been used for studying selective T-cell responses in autoimmune disease, alloreac...
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Article
Open AccessDownstream or upstream administration of P2Y12 receptor blockers in non-ST elevated acute coronary syndromes: study protocol for a randomized controlled trial
The optimal timing to administer a P2Y12 inhibitor in patients presenting with a non-ST elevation acute coronary syndrome remains a topic of debate. Pretreatment with ticagrelor before coronary anatomy is know...
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Article
Open AccessIn Vitro Comparison of the Effects of Imatinib and Ponatinib on Chronic Myeloid Leukemia Progenitor/Stem Cell Features
The development of molecularly tailored therapeutic agents such as the BCR/ABL-active tyrosine kinase inhibitors (TKi) resulted in an excellent treatment option for chronic myeloid leukemia (CML) patients. How...
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Article
Features, reason for testing, and changes with time of 583 paroxysmal nocturnal hemoglobinuria clones from 529 patients: a multicenter Italian study
In this study, we aimed at disclosing the main features of paroxysmal nocturnal hemoglobinuria (PNH) clones, their association with presentation syndromes, and their changes during follow-up. A large-scale, co...
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Article
Il referto citofluorimetrico
In Medicina di Laboratorio il momento del referto, oltre a rappresentare un evento essenziale nella validazione clinica di un risultato, assume anche il preciso significato di “giudizio interpretativo” formula...
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Article
Replicating neuroblastoma cells in different cell cycle phases display different vulnerability to amyloid toxicity
A key role of mitotic activation in neuronal cell death in early stages of Alzheimer’s disease (AD) has been suggested. Apparently, terminally differentiated neurons are precluded from mitotic division, yet so...
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Article
Medical treatment of eng-stage heart failure
Congestive heart failure is a lethal condition that affects an increasing number of patients. In recent years a great amount of data have accumulated on the pathophysiology and medical and surgical therapy of ...
