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Article
Open AccessA novel saliva-based miRNA profile to diagnose and predict oral cancer
Oral cancer (OC) is the most common form of head and neck cancer. Despite the high incidence and unfavourable patient outcomes, currently, there are no biomarkers for the early detection of OC. This study aims...
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Article
Open AccessDoes the registry speak your language? A case study of the Global Angelman Syndrome Registry
Global disease registries are critical to capturing common patient related information on rare illnesses, allowing patients and their families to provide information about their condition in a safe, accessible...
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Article
Open AccessFirst detection and complete genome sequence of a new potexvirus naturally infecting Adenium obesum
Here, we report the detection and complete genome sequence of a novel potexvirus, tentatively named “Adenium obesum virus X” (AobVX), isolated from Adenium obesum, that was sent for virus screening at Australian ...
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Article
Open AccessComplete genome sequence of a novel potyvirus infecting Miscanthus sinensis (silver grass)
Here, we describe the full-length genome sequence of a novel potyvirus, tentatively named “Miscanthus sinensis mosaic virus” (MsiMV), isolated from Miscanthus sinensis (silver grass) held in a post-entry quaranti...
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Article
Open AccessAuthor Correction: Aptamer-mediated survivin RNAi enables 5-fluorouracil to eliminate colorectal cancer stem cells
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Grapevine virus I, a putative new vitivirus detected in co-infection with grapevine virus G in New Zealand
A novel virus, with characteristics of viruses classified within the genus Vitivirus, was identified from a sample of Vitis vinifera cv. Chardonnay in New Zealand. The virus was detected with high throughput sequ...
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Article
Identification of a novel vitivirus from grapevines in New Zealand
We report a sequence of a novel vitivirus from Vitis vinifera obtained using two high-throughput sequencing (HTS) strategies on RNA. The initial discovery from small-RNA sequencing was confirmed by HTS of the tot...
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Chapter
The Expressed Portion of the Barley Genome
In this chapter, we refer to the expressed portion of the barley genome as the relatively small fraction of the total cellular DNA that either contains the genes that ultimately produce proteins, or that direc...
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Article
Open AccessAptamer-mediated survivin RNAi enables 5-fluorouracil to eliminate colorectal cancer stem cells
The development of chemoresistance and inability in elimination of cancer stem cells are among the key limitations of cancer chemotherapy. Novel molecular therapeutic strategies able to overcome such limitatio...
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Article
Open AccessConstruction of a map-based reference genome sequence for barley, Hordeum vulgare L.
Barley (Hordeum vulgare L.) is a cereal grass mainly used as animal fodder and raw material for the malting industry. The map-based reference genome sequence of barley cv. ‘Morex’ was constructed by the Internati...
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Article
Open AccessA chromosome conformation capture ordered sequence of the barley genome
Cereal grasses of the Triticeae tribe have been the major food source in temperate regions since the dawn of agriculture. Their large genomes are characterized by a high content of repetitive elements and larg...
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Article
Open AccessAn internet-based bioinformatics toolkit for plant biosecurity diagnosis and surveillance of viruses and viroids
Detection and preventing entry of exotic viruses and viroids at the border is critical for protecting plant industries trade worldwide. Existing post entry quarantine screening protocols rely on time-consuming...
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Article
Acetylcholinesterase 1 in populations of organophosphate-resistant North American strains of the cattle tick, Rhipicephalus microplus (Acari: Ixodidae)
Rhipicephalus microplus, the cattle fever tick, is a global economic problem to the cattle industry due to direct infestation of cattle and pathogens transmitted during feeding. Cattle fe...
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Article
Open AccessGenome sequencing and analysis of the paclitaxel-producing endophytic fungus Penicillium aurantiogriseum NRRL 62431
Paclitaxel (Taxol™) is an important anticancer drug with a unique mode of action. The biosynthesis of paclitaxel had been considered restricted to the Taxus species until it was discovered in Taxomyces andreanae,...
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Article
Open AccessA novel mutation causing nephronophthisis in the Lewis polycystic kidney rat localises to a conserved RCC1 domain in Nek8
Nephronophthisis (NPHP) as a cause of cystic kidney disease is the most common genetic cause of progressive renal failure in children and young adults. NPHP is characterized by abnormal and/or loss of function...
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Article
Open AccessDe novo assembly of Euphorbia fischeriana root transcriptome identifies prostratin pathway related genes
Euphorbia fischeriana is an important medicinal plant found in Northeast China. The plant roots contain many medicinal compounds including 12-deoxyphorbol-13-acetate, commonly known as prostratin that is a phorbo...
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Article
Open AccessEvolutionary conserved microRNAs are ubiquitously expressed compared to tick-specific miRNAs in the cattle tick Rhipicephalus (Boophilus) microplus
MicroRNAs (miRNAs) are small non-coding RNAs that act as regulators of gene expression in eukaryotes modulating a large diversity of biological processes. The discovery of miRNAs has provided new opportunities...
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Article
Diverse approaches to achieving grain yield in wheat
Artificial selection (domestication and breeding) leaves a strong footprint in plant genomes. Second generation high throughput DNA sequencing technologies make it possible to sequence the gene complement of a...
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Article
Open AccessEvidence of a tick RNAi pathway by comparative genomics and reverse genetics screen of targets with known loss-of-function phenotypes in Drosophila
The Arthropods are a diverse group of organisms including Chelicerata (ticks, mites, spiders), Crustacea (crabs, shrimps), and Insecta (flies, mosquitoes, beetles, silkworm). The cattle tick, Rhipicephalus (Booph...
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Article
A multilingual ontology for infectious disease surveillance: rationale, design and challenges
A lack of surveillance system infrastructure in the Asia-Pacific region is seen as hindering the global control of rapidly spreading infectious diseases such as the recent avian H5N1 epidemic. As part of impro...
