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  1. Article

    Open Access

    CDK5RAP2 is a Wnt target gene and promotes stemness and progression of oral squamous cell carcinoma

    In oral squamous cell carcinoma (OSCC), a highly aggressive and frequently lethal malignancy, the role and action mechanism of the microtubule regulatory protein CDK5RAP2 have not been fully understood. Here, ...

    Yuehong Shen, Yuling Chen, Yuntao Lin, Yicun Li, Pengfei Liu… in Cell Death & Disease (2023)

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    Detection and Analysis of Microtubule Nucleator γ-Tubulin Ring Complex

    Golgi-derived microtubules constitute an asymmetrical microtubule network that drives polarized transport of vesicles to support cell polarization and directional migration. Golgi-based microtubule nucleation ...

    Franco K. C. Au, Khoi T. D. Le, Robert Z. Qi in Golgi (2023)

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    Article

    The neuronal p35 activator of Cdk5 is a novel F-actin binding and bundling protein

    The neuronal Cdk5 activator p35 is involved in a multitude of neuronal activities, including cytoskeletal organization. We show here that p35 directly interacts with filamentous actin (F-actin) but not with mo...

    Lisheng He, Zhaojun Zhang, Yan Yu, Sohail Ahmed… in Cellular and Molecular Life Sciences (2011)

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    Chapter

    Protein–Protein Interactions Involving the N-Terminus of p35

    As a major regulator of Cdk5, the protein p35 exerts various effects on neuronal cells. Under certain conditions, p35 undergoes truncation of its N-terminus to form the protein p25. Although p25 is equally pot...

    Gary Kar Ho Ng, Lisheng He, Robert Z. Qi in Cyclin Dependent Kinase 5 (Cdk5) (2008)