-
Article
Slowing progression of autosomal dominant polycystic kidney disease
Autosomal dominant polycystic kidney disease is a challenging disorder to diagnose and treat effectively. Promising research over the past decade has, however, provided novel interventions, modifications to cl...
-
Article
Mineralocorticoid receptor antagonists as diuretics: Can congestive heart failure learn from liver failure?
Despite significant improvements in diagnosis, understanding the pathophysiology and management of the patients with acute decompensated heart failure (ADHF), diuretic resistance, yet to be clearly defined, is...
-
Article
The nephrotic syndrome: pathogenesis and treatment of edema formation and secondary complications
Nephrotic syndrome is an important clinical condition affecting both children and adults. Studies suggest that the pathogenesis of edema in individual patients may occur via widely variable mechanisms, i.e., i...
-
Article
Open AccessEffects of lovastatin treatment on the metabolic distributions in the Han:SPRD rat model of polycystic kidney disease
We previously demonstrated that lovastatin decreases cyst volume and improves kidney function in the Han:SPRD (Cy/+) rat model of ADPKD. Since endothelial dysfunction and inflammatory activity are evident in p...
-
Article
Cardiorenal Syndrome: Pathophysiology and Treatment
CRS is a common problem in patients with advanced heart failure. Arterial underfilling with consequent neurohormonal activation, systemic and intrarenal vasoconstriction, and salt and water retention cause the...
-
Article
Hyponatraemia: more than just a marker of disease severity?
Hyponatraemia—the most common serum electrolyte disorder—is an important marker of the severity and prognosis of a number of diseases. In this Review, Schrier et al. discuss the effect of hyponatraemia in differe...
-
Article
Glomerular hyperfiltration: definitions, mechanisms and clinical implications
Glomerular hyperfiltration occurs as a physiological response during pregnancy and after consumption of high-protein meals, but an elevation in glomerular filtration rate is also associated with various diseas...
-
Article
Limitations of angiotensin inhibition
Attempts to achieve pharmacological suppression of the renin–angiotensin–aldosterone system (RAAS) fall short of complete success, owing to the existence of accessory enzyme pathways. In this article, the ther...
-
Chapter
Pursuit of a Patient-Oriented Research Career as a Physician-Scientist
In the 1850s, my mother’s grandparents emigrated from Ireland at the time of the potato famine in that country. Bridget Kelly and John Moynahan married and settled in Lexington, Kentucky. Their son, James Moyn...
-
Article
NPG and the ISN
-
Article
Aggressively preventing diabetes
-
Article
Hyperkalemia: a threat to RAAS inhibition?
-
Article
Does 'asymptomatic hyponatremia' exist?
-
Article
ARF, AKI, or ATN?
-
Article
Aldosterone 'escape' vs 'breakthrough'
-
Article
Early intervention in acute kidney injury
The development of new biomarkers that enable the early diagnosis of acute kidney injury (AKI) should facilitate early intervention and reduce the mortality associated with this disease. In this Perspectives a...
-
Chapter
Acute Kidney Injury in Sepsis
Sepsis is the most common cause of acute kidney injury (AKI) in the intensive care unit. Mortality of AKI is much higher in septic patients compared with nonseptic patients. Septic patients frequently present ...
-
Chapter
Cardiorenal versus Renocardiac Syndrome
Many national registries and epidemiological observations have revealed a strong correlation between morbidity and mortality of patients with cardiovascular disease and kidney dysfunction. In patients with hea...
-
Article
AKI: fluid overload and mortality
-
Article
Cardiovascular abnormalities in autosomal-dominant polycystic kidney disease
This Review describes the cardiovascular manifestations of autosomal-dominant polycystic kidney disease (ADPKD), including hypertension, left ventricular hypertrophy, aneurysms and cardiac valvular disorders. ...
