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Article
Open AccessIn-office communication about excessive daytime sleepiness associated with treated obstructive sleep apnea: insights from an ethnographic study of physician-patient visits
Excessive daytime sleepiness (EDS), a primary symptom of obstructive sleep apnea (OSA), negatively affects functioning and quality of life (QoL). EDS can persist despite primary airway therapy, and often remai...
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Article
Open AccessPRIME-HCC: phase Ib study of neoadjuvant ipilimumab and nivolumab prior to liver resection for hepatocellular carcinoma
After liver resection (LR), patients with hepatocellular cancer (HCC) are at high risk of recurrence. There are no approved anti-cancer therapies known to affect such risk, highlighting the acute need for nove...
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Article
Open AccessA double-blind, randomised trial of a polyphenolic-rich nail bed balm for chemotherapy-induced onycholysis: the UK polybalm study
Nail damage is common amongst patients receiving chemotherapy causing disfigurement and pain. This investigation evaluated whether a topical balm containing steam-extracted, bioactive polyphenolic-rich herbal ...
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Article
Open AccessEcological Monitoring and Health Research in Luambe National Park, Zambia: Generation of Baseline Data Layers
Classifying, describing and understanding the natural environment is an important element of studies of human, animal and ecosystem health, and baseline ecological data are commonly lacking in remote environme...
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Article
Open AccessLook away: arterial and venous intravascular embolisation following shotgun injury
We describe two cases of intravascular embolization of shotgun pellets found distant to the entry site of penetrating firearm injury. The cases demonstrate antegrade embolization of a shotgun pellet from neck ...
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Article
Open AccessEarly pneumothorax as a feature of response to crizotinib therapy in a patient with ALK rearranged lung adenocarcinoma
Single arm phase 1 and 2 studies on Crizotinib in ALK-positive patients so far have shown rapid and durable responses. Spontaneous pneumothoraces as a result of response to anti-cancer therapy are rare in onco...
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Article
Open AccessDesmoplastic small round cell tumour: the radiological, pathological and clinical features
Desmoplastic small round cell tumours (DSRCTs) are rare aggressive tumours of young adults that present late and have poor prognosis. This review discusses distinctive radiological features, histopathology and...
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Article
How to reverse-engineer quality rankings
A good or bad product quality rating can make or break an organization. However, the notion of “quality” is often defined by an independent rating company that does not make the formula for determining the ran...
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Article
Open AccessEssential role for ALCAM gene silencing in megakaryocytic differentiation of K562 cells
Activated leukocyte cell adhesion molecule (ALCAM/CD166) is expressed by hematopoietic stem cells. However, its role in hematopoietic differentiation has not previously been defined.
