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Article
Open AccessStent-based delivery of AAV2 vectors encoding oxidation-resistant apoA1
In-stent restenosis (ISR) complicates revascularization in the coronary and peripheral arteries. Apolipoprotein A1 (apoA1), the principal protein component of HDL possesses inherent anti-atherosclerotic and an...
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Protocol
Stent-Based Gene Delivery for Coronary Disease
Percutaneous coronary interventions (PCI) are the mainstay for treatment of advanced coronary disease. A majority of PCI involve deployment of a stent in the affected vascular segment. This chapter introduces ...
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Article
Bioresorbable Scaffolds for Coronary Artery Disease
The purpose of this review is to present an overview of the recent evidence regarding the use of bioresorbable scaffolds in percutaneous coronary intervention.
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Article
New Insights into the Vulnerable Plaque from Imaging Studies
The concept of the vulnerable atherosclerotic plaque first developed through histological evaluation of post-mortem coronary arteries has been significantly advanced in recent years by new imaging modalities. ...
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Article
Intracoronary delivery of bone-marrow-derived stem cells
Ischemic heart disease is the single greatest killer of Americans and its complications are a major cause of congestive heart failure and ventricular arrhythmias while signifiicantly contributing to increased ...
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Article
Recent Developments with Lipoprotein-Associated Phospholipase A2 Inhibitors
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a calcium-independent phospholipase A2 enzyme secreted by leukocytes and associated with circulating low-density lipoprotein and macrophages in atherosclerotic...
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Article
Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development
Although increased levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) have been associated with cardiac disease, whether this enzyme has a causal role in the development of atherosclerosis has not bee...
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Article
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
We performed a genome-wide association scan to search for sequence variants conferring risk of prostate cancer using 1,501 Icelandic men with prostate cancer and 11,290 controls. Follow-up studies involving th...
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Article
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
We conducted a genome-wide association study for type 2 diabetes (T2D) in Icelandic cases and controls, and we found that a previously described variant in the transcription factor 7-like 2 gene (TCF7L2) gene con...
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Article
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
We recently described an association between risk of type 2diabetes and variants in the transcription factor 7-like 2 gene (TCF7L2; formerly TCF4), with a population attributable risk (PAR) of 17%–28% in three po...
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Article
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
We have previously reported suggestive linkage of type 2 diabetes mellitus to chromosome 10q1. We genotyped 228 microsatellite markers in Icelandic individuals with type 2 diabetes and controls throughout a 10.5-...
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Article
Angiotensin-Receptor Blockers: Revival of the Systemic Prevention of Restenosis?
Restenosis following percutaneous coronary transluminal angioplasty and stenting remains a significant problem, occurring in 15–50% of patients within 6–9 months of the intervention. Several pharmacological ap...
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Article
Gene delivery from a DNA controlled-release stent in porcine coronary arteries
Expandable intra-arterial stents are widely used for treating coronary disease. We hypothesized that local gene delivery could be achieved with the controlled release of DNA from a polymer coating on an expand...
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Chapter
Acute Myocardial Infarction
Each year in the United States alone, one and a half million patients suffer an acute myocardial infarction while the annual cost for the prevention and treatment of this illness is estimated to be over 50 bil...
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Chapter
Unstable Angina Pectoris
Cardiovascular disease affects one in five Americans and is the leading cause of mortality in the USA by accounting for 43% of all deaths. In 1994 the cost of cardiovascular disease to the American economy exc...
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Chapter
Interventional Approaches to the Treatment of Acute Coronary Ischemic Syndromes
In 1959 Sones and Shirley [1] introduced selective coronary angiography into clinical medicine heralding an era of visualization of the coronary arterial lumen. Although there is sufficient evidence to indicat...
