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  1. Article

    Open Access

    Flip-Flop HSV-BAC: bacterial artificial chromosome based system for rapid generation of recombinant herpes simplex virus vectors using two independent site-specific recombinases

    Oncolytic herpes simplex virus (HSV) vectors that specifically replicate in and kill tumor cells sparing normal cells are a promising cancer therapy. Traditionally, recombinant HSV vectors have been generated ...

    Toshihiko Kuroda, Robert L Martuza, Tomoki Todo, Samuel D Rabkin in BMC Biotechnology (2006)

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