32 Result(s)

Article

B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles

B cells are important in tuberculosis (TB) immunity, but their role in the human lung is understudied. Here, we characterize B cells from lung tissue and matched blood of patients with TB and found they are de...

Robert Krause, Paul Ogongo, Liku Tezera, Mohammed Ahmed… in Communications Biology (2024)

Article

Psychological flexibility as a mechanism of change in psilocybin-assisted therapy for major depression: results from an exploratory placebo-controlled trial

Several phase II studies have demonstrated that psilocybin-assisted therapy shows therapeutic potential across a spectrum of neuropsychiatric conditions, including major depressive disorder (MDD). However, the...

Jordan Sloshower, Richard J. Zeifman, Jeffrey Guss, Robert Krause… in Scientific Reports (2024)

Article

Implementation of an antimicrobial stewardship program for urinary tract infections in long-term care facilities: a cluster-controlled intervention study

Widespread inappropriate use of antimicrobial substances drives resistance development worldwide. In long-term care facilities (LTCF), antibiotics are among the most frequently prescribed medications. More tha...

Elisabeth König, Lisa Kriegl, Christian Pux… in Antimicrobial Resistance & Infection Contr… (2024)

Article

Soluble urokinase plasminogen activator receptor (suPAR) in bronchoalveolar fluid and blood in critically ill patients—a prospective cohort study

Soluble urokinase plasminogen activator receptor (suPAR) is a biologically active protein and increased levels are associated with worse outcomes in critically ill patients. suPAR in bronchoalveolar fluid (BAL...

Alexander C. Reisinger, Stefan Hatzl, Juergen Prattes, Gerald Hackl… in Infection (2024)

Article

Predictors for Prolonged Hospital Stay Solely to Complete Intravenous Antifungal Treatment in Patients with Candidemia: Results from the ECMM Candida III Multinational European Observational Cohort Study

To date, azoles represent the only viable option for oral treatment of invasive Candida infections, while rates of azole resistance among non-albicans Candida spp. continue to increase. The objective of this sub-...

Matthias Egger, Jon Salmanton-García, Aleksandra Barac… in Mycopathologia (2023)

Article

Mycobacterium tuberculosis senses host Interferon-γ via the membrane protein MmpL10

Mycobacterium tuberculosis (Mtb) is one of the most successful human pathogens. Several cytokines are known to increase virulence of bacterial pathogens, leading us to investigate whether Interferon-γ (IFN-γ), a ...

Mohamed Ahmed, Jared Mackenzie, Liku Tezera, Robert Krause… in Communications Biology (2022)

Article

The Antifungal Pipeline: Fosmanogepix, Ibrexafungerp, Olorofim, Opelconazole, and Rezafungin

The epidemiology of invasive fungal infections is changing, with new populations at risk and the emergence of resistance caused by the selective pressure from increased usage of antifungal agents in prophylaxi...

Martin Hoenigl, Rosanne Sprute, Matthias Egger, Amir Arastehfar, Oliver A. Cornely… in Drugs (2021)

Article

Antifungal prophylaxis for prevention of COVID-19-associated pulmonary aspergillosis in critically ill patients: an observational study

Coronavirus disease 19 (COVID-19)-associated pulmonary aspergillosis (CAPA) emerged as important fungal complications in patients with COVID-19-associated severe acute respiratory failure (ARF). Whether mould ...

Stefan Hatzl, Alexander C. Reisinger, Florian Posch, Juergen Prattes… in Critical Care (2021)

Article

Convalescent plasma therapy and mortality in COVID-19 patients admitted to the ICU: a prospective observational study

This study aimed to quantify the potential survival benefit of convalescent plasma therapy (CVP) in critically ill patients with acute respiratory failure related to coronavirus disease-2019 (COVID-19).

Stefan Hatzl, Florian Posch, Nazanin Sareban, Martin Stradner… in Annals of Intensive Care (2021)

Article

Efficacy of universal preoperative decolonization with Polyhexanide in primary joint arthroplasty on surgical site infections. A multicenter before-and after-study

Surgical site infections (SSI) are rare but severe complications after total joint arthroplasty (TJA). Decolonization measures prior to elective orthopedic surgeries have shown to reduce the risk of SSI with Stap...

Björn Wandhoff, Christin Schröder… in Antimicrobial Resistance & Infection Contr… (2020)

Article

Response to “COVID-19 in persons with haematological cancers”

Stefan Hatzl, Florian Eisner, Gernot Schilcher, Philipp Kreuzer… in Leukemia (2020)

Article

Space Station conditions are selective but do not alter microbial characteristics relevant to human health

The International Space Station (ISS) is a unique habitat for humans and microorganisms. Here, we report the results of the ISS experiment EXTREMOPHILES, including the analysis of microbial communities from se...

Maximilian Mora, Lisa Wink, Ines Kögler, Alexander Mahnert… in Nature Communications (2019)

Article

The impact of bacteremia on lipoprotein concentrations and patient’s outcome: a retrospective analysis

Bacteremia is a major clinical challenge requiring early treatment. Metabolic alterations occur during bacteremia, and accordingly plasma concentrations of lipoproteins LDL-C and HDL-C are substantially change...

Alex Pizzini, Katharina Kurz… in European Journal of Clinical Microbiology … (2019)

Article

Colonization of long term care facility patients with MDR-Gram-negatives during an Acinetobacter baumannii outbreak

We aimed to determine the prevalence of colonization by multidrug-resistant Gram-negative bacteria including ESBL-producing enterobacteriaceae, carbapenem-resistant enterobacteriaceae, Pseudomonas aeruginosa and

Ines Zollner-Schwetz, Elisabeth Zechner… in Antimicrobial Resistance & Infection Contr… (2017)

Article

Resilient microorganisms in dust samples of the International Space Station—survival of the adaptation specialists

The International Space Station (ISS) represents a unique biotope for the human crew but also for introduced microorganisms. Microbes experience selective pressures such as microgravity, desiccation, poor nutr...

Maximilian Mora, Alexandra Perras, Tatiana A. Alekhova, Lisa Wink… in Microbiome (2016)

Article

Abstracts from the 4th Grazer Risk Day: Patient Safety in Routine

A1 Meet the needs: Important questions for ICU relatives

Magdalena M. Hoffmann, Anna K. Holl, Harald Burgsteiner, Thomas Pieber… in Safety in Health (2016)

Article

Multicenter evaluation of a lateral-flow device test for diagnosing invasive pulmonary aspergillosis in ICU patients

The incidence of invasive pulmonary aspergillosis (IPA) in intensive care unit (ICU) patients is increasing, and early diagnosis of the disease and treatment with antifungal drugs is critical for patient survi...

Susanne Eigl, Juergen Prattes, Michaela Lackner, Birgit Willinger… in Critical Care (2015)

Article

Progressive alveolar echinococcosis after discontinuation of anthelmintic therapy

We report a case of a female patient with alveolar echinococcosis (AE) who presented with progressive pulmonary and hepatic lesions and had a fatal outcome. AE affecting the liver, the lungs and the brain had ...

Michael Meilinger, Christina Stoeckl, Marion Pollheimer, Peter Kern… in Parasites & Vectors (2013)