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    p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells

    CRISPR/Cas9 has revolutionized our ability to engineer genomes and conduct genome-wide screens in human cells1–3. Whereas some cell types are amenable to genome engineering, genomes of human pluripotent stem cell...

    Robert J. Ihry, Kathleen A. Worringer, Max R. Salick, Elizabeth Frias… in Nature Medicine (2018)