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  1. Article

    Open Access

    Deficiency of N-glycanase 1 perturbs neurogenesis and cerebral development modeled by human organoids

    Mutations in N-glycanase 1 (NGLY1), which deglycosylates misfolded glycoproteins for degradation, can cause NGLY1 deficiency in patients and their abnormal fetal development in multiple organs, including microcep...

    Victor J. T. Lin, Jiangnan Hu, Ashwini Zolekar, Max R. Salick… in Cell Death & Disease (2022)

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  2. Article

    Open Access

    CellSIUS provides sensitive and specific detection of rare cell populations from complex single-cell RNA-seq data

    We develop CellSIUS (Cell Subtype Identification from Upregulated gene Sets) to fill a methodology gap for rare cell population identification for scRNA-seq data. CellSIUS outperforms existing algorithms for s...

    Rebekka Wegmann, Marilisa Neri, Sven Schuierer, Bilada Bilican… in Genome Biology (2019)

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  3. No Access

    Article

    p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells

    CRISPR/Cas9 has revolutionized our ability to engineer genomes and conduct genome-wide screens in human cells1–3. Whereas some cell types are amenable to genome engineering, genomes of human pluripotent stem cell...

    Robert J. Ihry, Kathleen A. Worringer, Max R. Salick, Elizabeth Frias… in Nature Medicine (2018)

  4. No Access

    Chapter and Conference Paper

    Controlling hESC-CM Cell Morphology on Patterned Substrates Over a Range of Stiffness

    There is a consensus in the cardiac stem cell biology field that human embryonic stem cell derived–cardiomyocytes (hESC-CMs) are immature and do not resemble human adult cardiomyocytes, either phenotypically o...

    Brett N. Napiwocki, Max R. Salick… in Mechanics of Biological Systems and Materi… (2017)

  5. No Access

    Chapter and Conference Paper

    Polydimethylsiloxane Lanes Enhance Sarcomere Organization in Human ESC-Derived Cardiomyocytes

    Human embryonic stem cell–derived cardiomyocytes (hESC-CMs) hold great potential in many areas of research such as cardiac tissue regeneration, cardiotoxicity screening and human heart disease models; however,...

    Brett N. Napiwocki, Max R. Salick… in Mechanics of Biological Systems and Materi… (2016)

  6. No Access

    Article

    In vitro evaluations of electrospun nanofiber scaffolds composed of poly(ɛ-caprolactone) and polyethylenimine

    The work was intended to explore the effect of the widely available cationic polymer polyethylenimine (PEI) on small diameter poly(ɛ-caprolactone) (PCL) blood vessel grafts. PEI was blended with PCL and electr...

    **n **g, Hao-Yang Mi, Max R. Salick, Travis Cordie… in Journal of Materials Research (2015)

  7. No Access

    Article

    Poly(ε-caprolactone) (PCL)/cellulose nano-crystal (CNC) nanocomposites and foams

    Poly(ε-caprolactone) (PCL)/cellulose nanocrystal (CNC) nanocomposites were produced via twin-screw extrusion. Microcellular nanocomposite samples were produced with microcellular injection molding using carbo...

    Hao-Yang Mi, **n **g, Jun Peng, Max R. Salick, **ang-Fang Peng… in Cellulose (2014)

  8. No Access

    Article

    Fabrication of thermoplastic polyurethane tissue engineering scaffold by combining microcellular injection molding and particle leaching

    Microcellular injection molding, a process capable of mass-producing complex plastic parts, and particle leaching methods were combined to fabricate porous thermoplastic polyurethane tissue engineering scaffol...

    Hao-Yang Mi, **n **g, Max R. Salick, Lih-Sheng Turng… in Journal of Materials Research (2014)

  9. No Access

    Article

    Morphology, mechanical properties, and mineralization of rigid thermoplastic polyurethane/hydroxyapatite scaffolds for bone tissue applications: effects of fabrication approaches and hydroxyapatite size

    Rigid thermoplastic polyurethane (TPU)/hydroxyapatite (HA) scaffolds were prepared with micro HA (mHA) and nano HA (nHA) particles, respectively, via the thermally induced phase separation method. The effects ...

    Hao-Yang Mi, **n **g, Max R. Salick, Travis M. Cordie… in Journal of Materials Science (2014)