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Article
A shallow convolutional neural network predicts prognosis of lung cancer patients in multi-institutional computed tomography image datasets
Lung cancer is the most common fatal malignancy in adults worldwide, and non-small-cell lung cancer (NSCLC) accounts for 85% of lung cancer diagnoses. Computed tomography is routinely used in clinical practice...
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Article
Open AccessCorrection: Acidity promotes tumour progression by altering macrophage phenotype in prostate cancer
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessMix and Match: Phenotypic Coexistence as a Key Facilitator of Cancer Invasion
Invasion of healthy tissue is a defining feature of malignant tumours. Traditionally, invasion is thought to be driven by cells that have acquired all the necessary traits to overcome the range of biological a...
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Article
Open AccessRadiological semantics discriminate clinically significant grade prostate cancer
Identification of imaging traits to discriminate clinically significant prostate cancer is challenging due to the multi focal nature of the disease. The difficulty in obtaining a consensus by the Prostate Imag...
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Article
Open AccessAcidity promotes tumour progression by altering macrophage phenotype in prostate cancer
Tumours rapidly ferment glucose to lactic acid even in the presence of oxygen, and coupling high glycolysis with poor perfusion leads to extracellular acidification. We hypothesise that acidity, independent fr...
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Article
Climate of the weakly-forced yet high-impact convective storms throughout the Ohio River Valley and Mid-Atlantic United States
The 1-in-1000-year precipitation event in late June 2016 over West Virginia caused tremendous flooding damage. Like the 2012 mid-Atlantic derecho that blacked out much of the DC area, similar events can be tra...
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Article
Open AccessRevealing Tumor Habitats from Texture Heterogeneity Analysis for Classification of Lung Cancer Malignancy and Aggressiveness
We propose an approach for characterizing structural heterogeneity of lung cancer nodules using Computed Tomography Texture Analysis (CTTA). Measures of heterogeneity were used to test the hypothesis that hete...
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Article
Open AccessVoxel size and gray level normalization of CT radiomic features in lung cancer
Radiomic features are potential imaging biomarkers for therapy response assessment in oncology. However, the robustness of features with respect to imaging parameters is not well established. Previously identi...
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Article
Open AccessLinc-ing Circulating Long Non-coding RNAs to the Diagnosis and Malignant Prediction of Intraductal Papillary Mucinous Neoplasms of the Pancreas
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease that lacks effective biomarkers for early detection. We hypothesized that circulating long non-coding RNAs (lncRNAs) may act as diagnostic marke...
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Article
California from drought to deluge
The dramatic switch from extreme drought to severe flooding in California, and the accompanying flip from atmospheric ridge to trough in the northeastern Pacific, exemplifies the pathways to an intensified wat...
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Article
A Comparison of Lung Nodule Segmentation Algorithms: Methods and Results from a Multi-institutional Study
Tumor volume estimation, as well as accurate and reproducible borders segmentation in medical images, are important in the diagnosis, staging, and assessment of response to cancer therapy. The goal of this stu...
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Chapter and Conference Paper
Synthesis of Bivalent MSH Ligands and Evaluation of their Binding to hMC4R using MSH Lanthaligand
