7 Result(s)
within
Robert D. Finn
English
Computational Biology/Bioinformatics
Microarrays
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Article
Recovering prokaryotic genomes from host-associated, short-read shotgun metagenomic sequencing data
Recovering genomes from shotgun metagenomic sequence data allows detailed taxonomic and functional characterization of individual species or strains in a microbial community. Retrieving these metagenome-assemb...
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Article
Open AccessStructure and computational analysis of a novel protein with metallopeptidase-like and circularly permuted winged-helix-turn-helix domains reveals a possible role in modified polysaccharide biosynthesis
CA_C2195 from Clostridium acetobutylicum is a protein of unknown function. Sequence analysis predicted that part of the protein contained a metallopeptidase-related domain. There are over 200 homologs of similar ...
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Article
Open AccessSkylign: a tool for creating informative, interactive logos representing sequence alignments and profile hidden Markov models
Logos are commonly used in molecular biology to provide a compact graphical representation of the conservation pattern of a set of sequences. They render the information contained in sequence alignments or pro...
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Article
Open AccessTwo Pfam protein families characterized by a crystal structure of protein lpg2210 from Legionella pneumophila
Every genome contains a large number of uncharacterized proteins that may encode entirely novel biological systems. Many of these uncharacterized proteins fall into related sequence families. By applying seque...
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Article
Open AccessIntegrating biological data – the Distributed Annotation System
The Distributed Annotation System (DAS) is a widely adopted protocol for dynamically integrating a wide range of biological data from geographically diverse sources. DAS continues to expand its applicability a...
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Article
Open AccessIntegrating sequence and structural biology with DAS
The Distributed Annotation System (DAS) is a network protocol for exchanging biological data. It is frequently used to share annotations of genomes and protein sequence.
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Article
Open AccessPredicting active site residue annotations in the Pfam database
Approximately 5% of Pfam families are enzymatic, but only a small fraction of the sequences within these families (<0.5%) have had the residues responsible for catalysis determined. To increase the active site...
