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  1. No Access

    Article

    Preparations of Ψ-peptide bond and peptide-aldehyde inhibitors of atrial granule serine proteinase, a candidate processing enzyme of pro-atrial natriuretic factor

    Pseudo-peptide bond inhibitors (ψ-bond inhibitors) and peptide-aldehyde inhibitors of atrial granule serine proteinase, the candidate processing enzyme of pro-atrial natrieuretic factor, are prepared in high y...

    Ajit Damodaran, Robert B. Harris in Journal of Protein Chemistry (1995)

  2. No Access

    Article

    N-terminal sequence analysis of atrial granule serine proteinase purified by affinity chromatography

    Atrial granule serine proteinase is considered the leading candidate endoproteolytic processing enzyme of pro-atrial natriuretic factor. Its cleavage specificity is directed toward a monobasic amino acid proce...

    Ajit Damodaran, Robert B. Harris in Journal of Protein Chemistry (1995)

  3. No Access

    Article

    Proteolytic maturation of transforming growth factor-α

    Transforming growth factor-α (TGF-α) is a mitogenic peptide hormone produced extracellularly, by tumor cells, and by virally and chemically transformed cells in culture. TGF-α is almost certainly derived from ...

    Erika Cappelluti, Robert B. Harris in Perspectives in Drug Discovery and Design (1995)

  4. No Access

    Article

    Conformational analysis and proteolytic processing of synthetic pre-pro-GnRH/GAP protein

    Homogeneous pre-pro-GnRH/GAP protein was recently synthesized in 100 mg quantities by solid-phase methods and surprisingly, the synthetic pre-pro-protein, which normally does not escape the endoplasmic recticu...

    Jun-ling You, Saskia C. F. Milton… in Journal of Protein Chemistry (1993)

  5. No Access

    Article

    Calorimetric and spectroscopic examination of the solution phase structures of prekallikrein binding domain peptides of high molecular weight kininogen

    Unique sequence-binding sites are exposed on the surface of high molecular weight kininogen which complex prekallikrein or factor XI with high affinity and specificity. A sequence comprising 31 residues of the...

    Jun-ling You, J. Neel Scarsdale, Robert B. Harris in Journal of Protein Chemistry (1991)

  6. No Access

    Article

    Characterization of liver epithelial cells transfected withmyc and/orras oncogenes

    While many liver tumors contain activatedmyc andras oncogenes, the mechanisms by which these genes contribute to cellular transformation is poorly understood. Activated versions of the cellular oncogenes,c-myc an...

    Stephen C. Strom, John B. Faust, Erika Cappelluti… in Digestive Diseases and Sciences (1991)

  7. No Access

    Article

    Solution phase conformation studies of the prekallikrein binding domain of high molecular weight kininogen

    High molecular weight kininogen is a cofactor of the surface-dependent phase of the blood-clotting cascade. Unique sequence-binding sites are exposed on the surface of this glycoprotein which complex prekallik...

    J. Neel Scarsdale, Robert B. Harris in Journal of Protein Chemistry (1990)

  8. No Access

    Chapter

    Isolation and Sequencing of an Active-Site Peptide from Angiotensin I-Converting Enzyme

    A glutamic acid residue at the active-site of bovine lung antiotensin I-converting enzyme was esterified with p-[N,N-bis-(chloroethyl)amino]phenyl- butyryl-L-[U-14C]-Proline(chlorambucyl-L-[U-l4C]-L-Proline), an ...

    Robert B. Harris in Kinins IV (1986)

  9. No Access

    Article

    Molecular weights of antihaemophilic factor and von Willebrand factor proteins in human plasma

    HUMAN factor VIII contains at least two biological activities, antihaemophilic factor (AHF) and von Willebrand factor (VWF). When highly purified, factor VIII is estimated to have a molecular weight of over 1....

    JACK NEWMAN, ROBERT B. HARRIS, ALAN J. JOHNSON in Nature (1976)