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Chapter
The Reconstituted Acetylcholine Receptor
The nicotinic acetylcholine receptor (AChR) is the postsynaptic membrane protein that transduces the binding of acetylcholine (ACh) into the transient opening of a cation-selective channel. This signal-transdu...
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Chapter
The Molecular Basis of Neurotransmission: Structure and Function of the Nicotinic Acetylcholine Receptor
Acetylcholine was identified as the first neurotransmitter as a result of elegant experiments by Otto Loewi in 1921 who demonstrated that the vagus nerve liberates a substance that has an inhibitory effect on ...