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Article
Open AccessIntegrin α11β1 in tumor fibrosis: more than just another cancer-associated fibroblast biomarker?
There is currently an increased interest in understanding the role of the tumor microenvironment (TME) in tumor growth and progression. In this context the role of integrins in cancer-associated fibroblasts (C...
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Chapter
Integrins in Cancer: Refocusing on the Tumor Microenvironment
Despite having been characterized for several decades, the development of therapeutically useful compounds based on integrins has shown little success. In cancer biology, previous studies mainly focused on the...
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Protocol
Human Tumor Tissue-Based 3D In Vitro Invasion Assays
Here we describe a protocol to utilize human benign leiomyoma tissue in in vitro 3D model that enables an assessment of cell invasion. The chapter also describes detailed instructions for image analysis to qua...
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Article
Open AccessLack of collagen XV is protective after ischemic stroke in mice
Collagens are key structural components of basement membranes, providing a scaffold for other components or adhering cells. Collagens and collagen-derived active fragments contribute to biological activities s...
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Article
Open AccessSignificant Role of Collagen XVII And Integrin β4 in Migration and Invasion of The Less Aggressive Squamous Cell Carcinoma Cells
Collagen XVII and integrin α6β4 have well-established roles as epithelial adhesion molecules. Their binding partner laminin 332 as well as integrin α6β4 are largely recognized to promote invasion and metastasi...
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Article
Expression of VEGF and collagen XVIII in meningiomas: correlations with histopathological and MRI characteristics
The objective of this study was to assess the possibility of predicting histological characteristics of meningiomas on the basis of preoperative MRI and the correlation of the expression of vascular endothelia...
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Article
Open AccessEndostatin, an Inhibitor of Angiogenesis, Decreases After Bidirectional Superior Cavopulmonary Anastamosis
Pulmonary arteriovenous malformations (PAVMs) are a common source of morbidity after bidirectional superior cavopulmonary anastomosis (Glenn). The diversion of hepatic venous effluent away from the pulmonary c...
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Chapter
Experimental Tumour Models in Mice
The complex multistage processes of tumour initiation, progression and metastasis challenge the methods that are used in basic cancer biology research and anticancer drug development. Experimental tumour model...
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Article
Open AccessType XVIII collagen degradation products in acute lung injury
In acute lung injury, repair of the damaged alveolar-capillary barrier is an essential part of recovery. Endostatin is a 20 to 28 kDa proteolytic fragment of the basement membrane collagen XVIII, which has bee...
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Article
Collagen XVIII/endostatin shows a ubiquitous distribution in human ocular tissues and endostatin-containing fragments accumulate in ocular fluid samples
The endostatin domain of type XVIII collagen (ColXVIII) inhibits neovascularization and regulates cell migration and matrix turnover. This study was designed to demonstrate the protein and gene expression patt...
