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  1. Article

    Open Access

    Modeling the novel SERD elacestrant in cultured fulvestrant-refractory HR-positive breast circulating tumor cells

    Metastatic hormone receptor-positive (HR+) breast cancer initially responds to serial courses of endocrine therapy, but ultimately becomes refractory. Elacestrant, a new generation FDA-approved oral selective ...

    Taronish D. Dubash, Aditya Bardia, Brian Chirn… in Breast Cancer Research and Treatment (2023)

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  2. No Access

    Protocol

    Negative-Selection Enrichment of Circulating Tumor Cells from Peripheral Blood Using the Microfluidic CTC-iChip

    The ability to isolate and analyze rare circulating tumor cells (CTCs) holds the potential to increase our understanding of cancer evolution and allows monitoring of disease and therapeutic responses through a...

    Risa Burr, Jon F. Edd, Brian Chirn, Avanish Mishra, Daniel A. Haber… in Mammary Stem Cells (2022)

  3. No Access

    Article

    Integrating genomic features for non-invasive early lung cancer detection

    Radiologic screening of high-risk adults reduces lung-cancer-related mortality1,2; however, a small minority of eligible individuals undergo such screening in the United States3,4. The availability of blood-based...

    Jacob J. Chabon, Emily G. Hamilton, David M. Kurtz, Mohammad S. Esfahani… in Nature (2020)

  4. No Access

    Chapter

    Epithelial-Mesenchymal Plasticity in Circulating Tumor Cells, the Precursors of Metastasis

    Circulating tumor cells offer an unprecedented window into the metastatic cascade, and to some extent can be considered as intermediates in the process of metastasis. They exhibit dynamic oscillations in epith...

    Risa Burr, Christine Gilles… in Circulating Tumor Cells in Breast Cancer M… (2020)