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    Structural Basis for the Proinflammatory Cytokine Activity of High Mobility Group Box 1

    High mobility group box 1 (HMGB1), a ubiquitous DNA-binding protein, has been implicated as a proinflammatory cytokine and late mediator of lethal endotoxemia. HMGB1 is released by activated macrophages. It am...

    Jianhua Li, Riikka Kokkola, Siamak Tabibzadeh, Runkuan Yang… in Molecular Medicine (2003)