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Article
Open AccessConservation of Nonsense-Mediated mRNA Decay Complex Components Throughout Eukaryotic Evolution
Nonsense-mediated mRNA decay (NMD) is an essential eukaryotic process regulating transcript quality and abundance, and is involved in diverse processes including brain development and plant defenses. Although ...
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Article
Open AccessQuery-based biclustering of gene expression data using Probabilistic Relational Models
With the availability of large scale expression compendia it is now possible to view own findings in the light of what is already available and retrieve genes with an expression profile similar to a set of gen...
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Article
Advantages and limitations of current network inference methods
Recently several novel tools for inferring transcriptional networks from expression data have been developed. Computationally inferred interactions offer a use...
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Chapter
Systems Microbiology: Gaining Insights in Transcriptional Networks
Bacteria are able to adapt to continuously changing environmental conditions. This complex cellular behavior is mediated by the underlying transcriptional network. The advent of high-throughput techniques has ...
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Article
Open AccessComparative analysis of module-based versus direct methods for reverse-engineering transcriptional regulatory networks
A myriad of methods to reverse-engineer transcriptional regulatory networks have been developed in recent years. Direct methods directly reconstruct a network of pairwise regulatory interactions while module-b...
