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  1. Article

    Open Access

    Radiation exposure lymphocyte damage assessed by γ-H2AX level using flow cytometry

    DNA double-strand breaks (DSBs) are considered the most relevant lesions to the DNA damage of ionizing radiation (IR), and γ-H2AX foci in peripheral blood lymphocytes are regarded as an adequate marker for DSB...

    Zhuoqing Chen, Hiroshi Wakabayashi, Rie Kuroda, Hiroshi Mori… in Scientific Reports (2024)

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  2. No Access

    Article

    A case of neurodegenerative Langerhans cell histiocytosis exhibiting high osteopontin in cerebrospinal fluid without specific radiological abnormalities

    Neurodegenerative Langerhans cell histiocytosis (ND-LCH) manifests several years after onset of LCH, with progressive neurological symptoms and characteristic brain imaging features. Although ND-LCH has a dism...

    Yuta Sakai, Yasuhiro Ikawa, Mika Takenaka… in International Journal of Hematology (2023)

  3. No Access

    Article

    l-asparaginase as an efficient salvage therapy for refractory acute myeloid leukemia with chromosome 7 abnormalities: a case series

    Acute myeloid leukemia (AML) with chromosome 7 abnormalities has a dismal prognosis due to a poor complete remission (CR) rate after induction chemotherapy. Although various salvage therapies for refractory AM...

    Kazuhiro Noguchi, Yasuhiro Ikawa, Mika Takenaka… in International Journal of Hematology (2023)

  4. No Access

    Article

    Phase I/II clinical trial of high-dose [131I] meta-iodobenzylguanidine therapy for high-risk neuroblastoma preceding single myeloablative chemotherapy and haematopoietic stem cell transplantation

    Paediatric high-risk neuroblastoma has poor prognosis despite modern multimodality therapy. This phase I/II study aimed to determine the safety, dose-limiting toxicity (DLT), and efficacy of high-dose 131I-meta-i...

    Rie Kuroda, Hiroshi Wakabayashi, Raita Araki… in European Journal of Nuclear Medicine and M… (2022)

  5. No Access

    Article

    Utility of 18F-FDG-PET for detecting acute lymphoblastic leukemia: a case series of pediatric acute lymphoblastic leukemia without hematological symptoms

    Acute leukemia is typically diagnosed from presenting features related to hematological symptoms, but certain patients present with prominent musculoskeletal pain without signs of hematological abnormality. We...

    Yasuhiro Ikawa, Mika Takenaka, Yuta Sakai… in International Journal of Hematology (2022)

  6. No Access

    Article

    High-dose 131I-mIBG as consolidation therapy in pediatric patients with relapsed neuroblastoma and ganglioneuroblastoma: the Japanese experience

    Children with relapsed neuroblastoma have a poor prognosis despite modern multimodality therapy. Novel and more effective therapeutic strategies are required for relapsed neuroblastoma. We retrospectively exam...

    Hiroshi Wakabayashi, Daiki Kayano, Anri Inaki, Raita Araki… in Annals of Nuclear Medicine (2020)

  7. No Access

    Article

    High-dose 131I-metaiodobenzylguanidine therapy in patients with high-risk neuroblastoma in Japan

    The aim of the study was to investigate the outcomes and prognostic factors of high-dose 131I-metaiodobenzylguanidine (131I-MIBG) therapy in patients with refractory or relapsed neuroblastoma (NBL) in Japan.

    Daiki Kayano, Hiroshi Wakabayashi, Kenichi Nakajima… in Annals of Nuclear Medicine (2020)

  8. No Access

    Article

    A characteristic flow cytometric pattern with broad forward scatter and narrowed side scatter helps diagnose immune thrombocytopenia (ITP)

    Various disorders cause severe thrombocytopenia, which can lead to critical hemorrhage. Procedures that rapidly support the diagnosis and risk factors for serious bleeding were explored, with a focus on immune...

    Raita Araki, Ryosei Nishimura, Rie Kuroda… in International Journal of Hematology (2018)