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Open AccessAdverse Events to SARS-CoV-2 (COVID-19) Vaccines and Policy Considerations that Inform the Funding of Safety Surveillance in Low- and Middle-Income Countries: A Mixed Methods Study
Rapid global approval of coronavirus disease 2019 (COVID-19) vaccines and concurrent introduction in high-income countries and low- and middle-income countries (LMIC) highlights the importance of equitable saf...
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Article
Comment on “Deterministic Sensitivity Analysis Under Ignorance”
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Open AccessThe Application and Implications of Novel Deterministic Sensitivity Analysis Methods
Deterministic sensitivity analyses (DSA) remain important to interpret the effect of uncertainties in individual parameters on results of cost-effectiveness analyses. Classic DSA methodologies may lead to wron...
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Article
Open AccessIncreasing the information provided by probabilistic sensitivity analysis: The relative density plot
Results of probabilistic sensitivity analyses (PSA) are frequently visualized as a scatterplot, which is limited through overdrawing and a lack of insight in relative density. To overcome these limitations, we...
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Article
Open AccessA novel method for predicting the budget impact of innovative medicines: validation study for oncolytics
High budget impact (BI) estimates of new drugs have led to decision-making challenges potentially resulting in restrictions in patient access. However, current BI predictions are rather inaccurate and short te...
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Article
Open AccessPhase I/II Clinical Trial-Based Early Economic Evaluation of Acalabrutinib for Relapsed Chronic Lymphocytic Leukaemia
The objective of this study was to construct an early economic evaluation for acalabrutinib for relapsed chronic lymphocytic leukaemia (CLL) to assist early reimbursement decision making. Scenarios were assess...
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Article
Effects of alcohol hangover on simulated highway driving performance
The purpose of this study was to examine the effects of alcohol hangover on simulated highway driving performance.