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The physiological role of β-cell heterogeneity in pancreatic islet function
Endocrine cells within the pancreatic islets of Langerhans are heterogeneous in terms of transcriptional profile, protein expression and the regulation of hormone release. Even though this heterogeneity has lo...
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Open AccessThe Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis
To discuss advances in our understanding of beta-cell heterogeneity and the ramifications of this for type 1 diabetes (T1D) and its therapy.