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Open AccessRevealing the tissue-level complexity of endogenous glucagon-like peptide-1 receptor expression and signaling
The glucagon-like peptide-1 receptor (GLP1R) is a class B G protein-coupled receptor (GPCR) involved in glucose homeostasis and food intake. GLP1R agonists (GLP1RA) are widely used in the treatment of diabetes...
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Article
Open AccessAuthor Correction: PDX1LOW MAFALOW β-cells contribute to islet function and insulin release
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Article
Author Correction: Optical control of L-type Ca2+ channels using a diltiazem photoswitch
A Correction to this paper has been published: https://doi.org/10.1038/s41589-021-00744-3.
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Article
Open AccessPDX1LOW MAFALOW β-cells contribute to islet function and insulin release
Transcriptionally mature and immature β-cells co-exist within the adult islet. How such diversity contributes to insulin release remains poorly understood. Here we show that subtle differences in β-cell maturi...
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Article
Open AccessAuthor Correction: Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessMaternal hypothyroidism in mice influences glucose metabolism in adult offspring
During pregnancy, maternal metabolic disease and hormonal imbalance may alter fetal beta cell development and/or proliferation, thus leading to an increased risk for develo** type 2 diabetes in adulthood. Al...
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Article
Open AccessStructure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes
Progressive decline in functional beta cell mass is central to the development of type 2 diabetes. Elevated serum levels of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) are associated with bet...
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Article
Open AccessSuper-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics
The glucagon-like peptide-1 receptor (GLP1R) is a class B G protein-coupled receptor (GPCR) involved in metabolism. Presently, its visualization is limited to genetic manipulation, antibody detection or the us...
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Article
Leader β-cells coordinate Ca2+ dynamics across pancreatic islets in vivo
Pancreatic β-cells form highly connected networks within isolated islets. Whether this behaviour pertains to the situation in vivo, after innervation and during continuous perfusion with blood, is unclear. In ...
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Article
Optical tools for understanding the complexity of β-cell signalling and insulin release
Following stimulation, pancreatic β-cells must orchestrate a plethora of signalling events to ensure the appropriate release of insulin and maintenance of normal glucose homeostasis. Failure at any point in th...
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Article
Open AccessThe Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis
To discuss advances in our understanding of beta-cell heterogeneity and the ramifications of this for type 1 diabetes (T1D) and its therapy.
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Article
Optical control of L-type Ca2+ channels using a diltiazem photoswitch
L-type Ca2+ channels (LTCCs) play a crucial role in excitation–contraction coupling and release of hormones from secretory cells. They are targets of antihypertensive and antiarrhythmic drugs such as diltiazem. H...
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Article
Author Correction: Beta cell connectivity in pancreatic islets: a type 2 diabetes target?
The original version of this article unfortunately contained a mistake. Legends of Figures 1 and 2 were interchanged. The correct versions are given below.
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Article
An updated view of hypothalamic–vascular–pituitary unit function and plasticity
The activity of hypothalamic neurons is modified by inputs leading to heterogeneous activity; a small proportion of the total population can drive pituitary ho...
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Article
Open AccessRemote control of glucose homeostasis in vivo using photopharmacology
Photopharmacology describes the use of light to precisely deliver drug activity in space and time. Such approaches promise to improve drug specificity by reducing off-target effects. As a proof-of-concept, we ...
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Article
Photoswitchable diacylglycerols enable optical control of protein kinase C
A photoswitchable diacylglycerol enables spatiotemporal control of membrane translocation of C1-domain-containing proteins and protein kinase C activation to modulate calcium oscillations and vesicle release f...
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Article
Open AccessSomatostatin triggers rhythmic electrical firing in hypothalamic GHRH neurons
Hypothalamic growth hormone-releasing hormone (GHRH) neurons orchestrate body growth/maturation and have been implicated in feeding responses and ageing. However, the electrical patterns that dictate GHRH neur...
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Article
Roles of connexins and pannexins in (neuro)endocrine physiology
To ensure appropriate secretion in response to demand, (neuro)endocrine tissues liberate massive quantities of hormones, which act to coordinate and synchronize biological signals in distant secretory and nons...
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Article
Beta cell connectivity in pancreatic islets: a type 2 diabetes target?
Beta cell connectivity describes the phenomenon whereby the islet context improves insulin secretion by providing a three-dimensional platform for intercellular signaling processes. Thus, the precise flow of i...
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Article
Open AccessOptical control of insulin release using a photoswitchable sulfonylurea
Sulfonylureas are widely prescribed for the treatment of type 2 diabetes mellitus (T2DM). Through their actions on ATP-sensitive potassium (KATP) channels, sulfonylureas boost insulin release from the pancreatic ...
