45 Result(s)

Article

Neurofibromatosis type 1 gene product (neurofibromin) associates with microtubules

The neurofibromatosis type 1 (NF1) gene was recently identified by positional cloning and found to encode a protein with structural and functional homology to mammalian and yeast GTPase-activating proteins (GA...

Paula E. Gregory, David H. Gutmann, Anna Mitchell… in Somatic Cell and Molecular Genetics (1993)

Article

Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential

Recent data suggest that signal transduction may have a critical role in the development and regulation of the metastatic phenotype. Here, we investigated the role of c-Src activation in the process of human c...

Weiguang Mao, Rosalyn Irby, Domenico Coppola, Ling Fu, Marek Wloch, Joel Turner… in Oncogene (1997)

Chapter

Inhibition of Neurofibromin and p120 GTPASE Activating Protein (GAP) by Dietary Fatty Acids

Neurofibromin and p120 GTPase activating protein (p120 GAP) down-regulate the activity of cellular Ras proteins. How the activity of these two proteins is controlled is not yet clear. In this study, we analyze...

Joung H. Lee, Jyoti A. Harwalkar… in Eicosanoids and Other Bioactive Lipids in … (1999)

Article

Activating SRC mutation in a subset of advanced human colon cancers

The discovery of Rous sarcoma virus (RSV) led to the identification of cellular Src (c–Src), a non-receptor tyrosine kinase, which has since been implicated in the development of numerous human cancers^1,2,3,4. c-...

Rosalyn B. Irby, Weiguang Mao, Domenico Coppola, Jimmy Kang… in Nature Genetics (1999)

Article

Inhibition of pp60^c-Src reduces Bcl-X_L expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors

Tumors that overexpress HER-2/neu receptor or exhibit enhanced EGFR signaling have been reported to possess constitutively activated Src family kinases, especially pp60^c-Src. High levels of pp60^c-Src activity hav...

Rotem Karni, Richard Jove, Alexander Levitzki in Oncogene (1999)

Article

Activation of Stat3 preassembled with platelet-derived growth factor β receptors requires Src kinase activity

Members of the STAT family of transcriptional regulators modulate the expression of a variety of gene products that promote cell proliferation, survival and transformation. Although initially identified as med...

Yi-Zhe Wang, Walker Wharton, Roy Garcia, Alan Kraker, Richard Jove, W J Pledger in Oncogene (2000)

Article

Preface: STAT signaling

Richard Jove in Oncogene (2000)

Article

STATs in oncogenesis

Since their discovery as key mediators of cytokine signaling, considerable progress has been made in defining the structure-function relationships of Signal Transducers and Activators of Transcription (STATs)....

Tammy Bowman, Roy Garcia, James Turkson, Richard Jove in Oncogene (2000)

Article

Induction of p21^WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling

While the activated viral Src oncoprotein, v-Src, induces uncontrolled cell growth, the mechanisms underlying cell cycle deregulation by v-Src have not been fully defined. Previous studies demonstrated that v-...

Dominic Sinibaldi, Walker Wharton, James Turkson, Tammy Bowman… in Oncogene (2000)

Article

STAT proteins: novel molecular targets for cancer drug discovery

Signal Transducers and Activators of Transcription (STATs) are a family of cytoplasmic proteins with roles as signal messengers and transcription factors that participate in normal cellular responses to cytoki...

James Turkson, Richard Jove in Oncogene (2000)

Reference Work Entry In depth

Signal Transducers and Activators of Transcription in Oncogenesis

Roy Garcia, Richard Jove in Encyclopedic Reference of Cancer (2001)

Article

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

Constitutive activation of signal transducer and activator of transcription (STAT) proteins has been detected in a wide variety of human primary tumor specimens and tumor cell lines including blood malignancie...

Roy Garcia, Tammy L Bowman, Guilian Niu, Hua Yu, Sue Minton… in Oncogene (2001)

Article

Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis

Hepatocyte Growth Factor/Scatter Factor (HGF/SF) mediates a wide variety of cellular responses by acting through the Met tyrosine kinase receptor. Inappropriate expression of HGF/SF and/or Met has been found i...

Yu-Wen Zhang, Ling-Mei Wang, Richard Jove, George F Vande Woude in Oncogene (2002)

Article

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

Non-receptor and receptor tyrosine kinases, such as Src and EGF receptor (EGFR), are major inducers of vascular endothelial growth factor (VEGF), one of the most potent mediators of angiogenesis. While tyrosin...

Guilian Niu, Kenneth L Wright, Mei Huang, Lanxi Song, Eric Haura, James Turkson… in Oncogene (2002)

Article

MEKK1-induced apoptosis requires TRAIL death receptor activation and is inhibited by AKT/PKB through inhibition of MEKK1 cleavage

MEK kinase 1 (MEKK1) induces apoptosis through the activation of caspases. The mechanism for MEKK1-induced apoptosis involves caspase-mediated cleavage of MEKK1, releasing a pro-apoptotic 91 kDa kinase fragmen...

Andrea H Bild, Francisco J Mendoza, Erika M Gibson, Mei Huang… in Oncogene (2002)

Article

Roles of activated Src and Stat3 signaling in melanoma tumor cell growth

Activation of protein tyrosine kinases is prevalent in human cancers and previous studies have demonstrated that Stat3 signaling is a point of convergence for many of these tyrosine kinases. Moreover, a critic...

Guilian Niu, Tammy Bowman, Mei Huang, Steve Shivers, Douglas Reintgen… in Oncogene (2002)

Article

Identification of Src transformation fingerprint in human colon cancer

We used a classical rodent model of transformation to understand the transcriptional processes, and hence the molecular and cellular events a given cell undergoes when progressing from a normal to a transforme...

Renae L Malek, Rosalyn B Irby, Qingbin M Guo, Kerry Lee, Sylvia Wong, Mei He… in Oncogene (2002)