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  1. No Access

    Reference Work Entry In depth

    Signal Transducers and Activators of Transcription in Oncogenesis

    Ralf Buettner, Roy Garcia, Richard Jove in Encyclopedia of Cancer (2017)

  2. No Access

    Chapter

    Historical Development of STAT3 Inhibitors and Early Results in Clinical Trials

    Since the initial reports of constitutive STAT3 activation in cells transformed by viral oncoproteins, the critical role of STAT3 signaling in human cancers has been firmly established. Detailed understanding ...

    Chao-Lan Yu, Richard Jove, James Turkson in STAT Inhibitors in Cancer (2016)

  3. Article

    Open Access

    Synergistic anti-tumor effect of combined inhibition of EGFR and JAK/STAT3 pathways in human ovarian cancer

    The EGFR signaling pathway is frequently activated in human ovarian cancer and associated with poor prognosis. However, inhibition of EGFR signaling in patients with recurrent ovarian cancer has been disappoin...

    Wei Wen, Jun Wu, Lucy Liu, Yan Tian, Ralf Buettner, Meng-Yin Hsieh… in Molecular Cancer (2015)

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  4. No Access

    Living Reference Work Entry In depth

    Signal Transducers and Activators of Transcription in Oncogenesis

    Ralf Buettner, Roy Garcia, Richard Jove in Encyclopedia of Cancer

  5. No Access

    Article

    Revisiting STAT3 signalling in cancer: new and unexpected biological functions

  6. The Janus kinases (JAKs) are major activators of signal transducer and activator of transcription (STAT) proteins. JAK–STAT3 signalling is crucial for cancer d...

    7. Hua Yu, Heehyoung Lee, Andreas Herrmann, Ralf Buettner… in Nature Reviews Cancer (2014)

  7. No Access

    Reference Work Entry In depth

    Signal Transducers and Activators of Transcription in Oncogenesis

    Ralf Buettner, Richard Jove, Roy Garcia in Encyclopedia of Cancer (2011)

  8. No Access

    Article

    STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors

    Physiological Stat3 signaling is temporally restricted. In cancer, Stat3 activity is often persistently elevated and fosters progression through its effects on tumor cells and their microenvironment. This repo...

    Heehyoung Lee, Jiehui Deng, Maciej Kujawski, Chunmei Yang, Yong Liu… in Nature Medicine (2010)

  9. No Access

    Article

    STATs in cancer inflammation and immunity: a leading role for STAT3

  10. Signal transducer and activator of transcription (STAT) proteins have dual roles: they transduce signals through the cytoplasm and function as transcription fa...

    11. Hua Yu, Drew Pardoll, Richard Jove in Nature Reviews Cancer (2009)

  11. No Access

    Reference Work Entry In depth

    Signal Transducers and Activators of Transcription in Oncogenesis

    Ralf Buettner, Roy Garcia, Richard Jove in Encyclopedia of Cancer (2009)

  12. No Access

    Article

    Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

    The immune system can act as an extrinsic suppressor of tumors. Therefore, tumor progression depends in part on mechanisms that downmodulate intrinsic immune surveillance. Identifying these inhibitory pathways...

    Marcin Kortylewski, Maciej Kujawski, Tianhong Wang, Sheng Wei… in Nature Medicine (2005)

  13. No Access

    Article

    Targeting STAT3 affects melanoma on multiple fronts

    As a point of convergence for numerous oncogenic signaling pathways, STAT3 is constitutively-activated at 50 to 90% frequency in diverse human cancers, including melanoma. A critical role of STAT3 in tumor cel...

    Marcin Kortylewski, Richard Jove, Hua Yu in Cancer and Metastasis Reviews (2005)

  14. Article

    Correction: Corrigendum: Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

    Nat. Med. 10, 48–54 (2004) In Figure 3c, the x-axis label for the second bar from the left was incorrect. The label should read, “Stat-3β”. In Figure 4e (top), the y-axis label was incorrect. The label should ...

    Tianhong Wang, Guilian Niu, Marcin Kortylewski, Lyudmila Burdelya… in Nature Medicine (2004)

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  15. No Access

    Article

    The STATs of cancer — new molecular targets come of age

  16. Signal transducer and activator of transcription (STAT)-family proteins are latent cytoplasmic transcription factors that convey signals from cytokine and grow...

    17. Hua Yu, Richard Jove in Nature Reviews Cancer (2004)

  17. No Access

    Article

    Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

    Although tumor progression involves processes such as tissue invasion that can activate inflammatory responses, the immune system largely ignores or tolerates disseminated cancers. The mechanisms that block in...

    Tianhong Wang, Guilian Niu, Marcin Kortylewski, Lyudmila Burdelya… in Nature Medicine (2004)

  18. Article

    Defining a molecular fingerprint of STAT3-regulated genes associated with oncogenesis using microarray technology and novel statistical methods

    Dominic Sinibaldi, Roy Garcia, Greg Bloom, Shrikant Mane, Peter Geiser… in Nature Genetics (2001)

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  19. No Access

    Reference Work Entry In depth

    Signal Transducers and Activators of Transcription in Oncogenesis

    Roy Garcia, Richard Jove in Encyclopedic Reference of Cancer (2001)

  20. Article

    Use of the Rat Gene Index to examine gene expression patterns from Src-transformed rat fibroblasts that exhibit broad differences in metastatic potential

    Renae L. Malek, Qingbin Guo, Mauro Ruffy, Edison T. Liu, Ingeborg Holt… in Nature Genetics (1999)

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  21. No Access

    Article

    Activating SRC mutation in a subset of advanced human colon cancers

    The discovery of Rous sarcoma virus (RSV) led to the identification of cellular Src (c–Src), a non-receptor tyrosine kinase, which has since been implicated in the development of numerous human cancers1,2,3,4. c-...

    Rosalyn B. Irby, Weiguang Mao, Domenico Coppola, Jimmy Kang… in Nature Genetics (1999)

  22. No Access

    Article

    Neurofibromatosis type 1 gene product (neurofibromin) associates with microtubules

    The neurofibromatosis type 1 (NF1) gene was recently identified by positional cloning and found to encode a protein with structural and functional homology to mammalian and yeast GTPase-activating proteins (GA...

    Paula E. Gregory, David H. Gutmann, Anna Mitchell… in Somatic Cell and Molecular Genetics (1993)