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  1. Article

    Open Access

    SN38 loaded nanostructured lipid carriers (NLCs); preparation and in vitro evaluations against glioblastoma

    SN38 is the active metabolite of irinotecan with 1000-fold greater cytotoxicity compared to the parent drug. Despite the potential, its application as a drug is still seriously limited due to its stability con...

    Ali Sabouri Shirazi, Reyhaneh Varshochian… in Journal of Materials Science: Materials in… (2021)

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    Article

    Mesoporous silica coated SPIONs containing curcumin and silymarin intended for breast cancer therapy

    Super-paramagnetic iron oxide nanoparticles (SPIONs) are known as promising theranostic nano-drug carriers with magnetic resonance imaging (MRI) properties. Applying the herbaceous components with cytotoxic ef...

    Soosan Sadegha, Reyhaneh Varshochian… in DARU Journal of Pharmaceutical Sciences (2022)

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    Article

    Teriflunomide Loaded SPION Nanoparticles Induced Apoptosis in MDA-MB-231 Breast Cancer Cells

    Teriflunomide (TFN), an immunomodulatory drug, has demonstrated cytotoxic effects in recent studies. This potential can be combined with nano-drug delivery to achieve an improved anticancer formulation.

    Tina Rabizadeh, Reyhaneh Varshochian, Athar Mahdieh… in Journal of Cluster Science (2023)

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    Article

    Self-assembled NIPAM–PEG–NIPAM polymeric nanomicelles for the delivery of zinc protoporphyrin: a potential stimuli-triggered cancer treatment approach

    Zinc protoporphyrin (ZnPP), known as a heme-oxygenase inhibitor, acts as an anticancer agent mainly by increasing free radical levels in the target cells and inducing cell death. However, its efficacy is restr...

    Marjan Bagheri-Meyabad, Hamidreza Motasadizadeh… in Journal of Materials Science (2024)