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  1. Article

    Open Access

    LOGGIC/FIREFLY-2: a phase 3, randomized trial of tovorafenib vs. chemotherapy in pediatric and young adult patients with newly diagnosed low-grade glioma harboring an activating RAF alteration

    Pediatric low-grade glioma (pLGG) is essentially a single pathway disease, with most tumors driven by genomic alterations affecting the mitogen-activated protein kinase/ERK (MAPK) pathway, predominantly KIAA1549:...

    Cornelis M. van Tilburg, Lindsay B. Kilburn, Sébastien Perreault in BMC Cancer (2024)

  2. No Access

    Chapter

    Der Einsatz des Telefons im Direktmarketing

    Das Telefonat unterscheidet sich vom persönlichen Gespräch. Beim persönlichen Gespräch werden Gestik und Mimik des Gegenübers wahrgenommen. Dies hilft für das Verständnis. Gestik und Mimik können gezielt einge...

    Torsten Spandl, René Schmidt in Direktmarketing mit dem Telefon (2022)

  3. No Access

    Chapter

    Umsetzung des Direktmarketings mit dem Telefon

    Jetzt wird es praktisch in diesem essential. Die folgenden Abschnitte beschäftigen sich mit vielen weiteren Tipps und Tricks für erfolgreiches telefonisches Direktmarketing.

    Torsten Spandl, René Schmidt in Direktmarketing mit dem Telefon (2022)

  4. No Access

    Chapter

    Einführung

    Telefon und Smartphone sind wichtige Instrumente für erfolgreiches Marketing und zielgerichteten Vertrieb. Gespräche finden direkt und unmittelbar statt. Anrufende bekommen konkrete Rückmeldungen zu den Anlieg...

    Torsten Spandl, René Schmidt in Direktmarketing mit dem Telefon (2022)

  5. No Access

    Book

    Direktmarketing mit dem Telefon

    Kompaktes Wissen für den erfolgreichen telefonischen Kundendialog

    Prof. Dr. Torsten Spandl, René Schmidt in essentials (2022)

  6. No Access

    Chapter

    Erfolgsfaktoren für Direktmarketing mit dem Telefon

    Telefonate als Direktmarketinginstrument werden strategisch geplant. Auch wenn jedes Gespräch individuell verläuft, können wesentliche Eckpunkte vorab definiert und ausgearbeitet werden. Über passende Aufhänge...

    Torsten Spandl, René Schmidt in Direktmarketing mit dem Telefon (2022)

  7. Article

    Open Access

    OF-Pelvis classification of osteoporotic sacral and pelvic ring fractures

    Osteoporotic fractures of the pelvis (OFP) are an increasing issue in orthopedics. Current classification systems (CS) are mostly CT-based and complex and offer only moderate to substantial inter-rater reliabi...

    Bernhard W. Ullrich, Klaus J. Schnake, Ulrich J. A. Spiegl in BMC Musculoskeletal Disorders (2021)

  8. No Access

    Article

    Therapie einer nekrotisierenden Weichgewebeinfektion

    Geschildert wird das chirurgische Vorgehen bei vital bedrohlichem Verlauf einer nekrotisierenden Weichgewebeinfektion des linken Beins nach Bagatelltrauma. Durch die erforderliche konsequente Resektion ausgede...

    Marion Riehle, René Schmidt in Der Unfallchirurg (2020)

  9. Article

    Open Access

    Effects of system response delays on elderly humans’ cognitive performance in a virtual training scenario

    Observed influences of system response delay in spoken human-machine dialogues are rather ambiguous and mainly focus on perceived system quality. Studies that systematically inspect effects on cognitive perfor...

    Maria Wirzberger, René Schmidt, Maria Georgi, Wolfram Hardt in Scientific Reports (2019)

  10. No Access

    Article

    Quantitative Rapid Assessment of Leukoaraiosis in CT

    The severity of white matter lesions (WML) is a risk factor of hemorrhage and predictor of clinical outcome after ischemic stroke; however, in contrast to magnetic resonance imaging (MRI) reliable quantificati...

    Uta Hanning, Peter Bernhard Sporns, Rene Schmidt in Clinical Neuroradiology (2019)

  11. No Access

    Article

    Efficacy and safety of alemtuzumab versus fingolimod in RRMS after natalizumab cessation

    Natalizumab (NTZ) was the first approved monoclonal antibody for the treatment of relapsing-remitting multiple sclerosis (RRMS). Despite proven and sustained efficacy, its use is limited by the risk of progres...

    Steffen Pfeuffer, Rene Schmidt, Frederike Anne Straeten, Refik Pul in Journal of Neurology (2019)

  12. No Access

    Article

    Finding an upper limit of what might be achievable by patients: oral cleanliness in dental professionals after self-performed manual oral hygiene

    Though patients have been shown to have difficulties in achieving oral cleanliness after self-performed oral hygiene, scientifically and empirically justified standards for the degree of oral cleanliness they ...

    Renate Deinzer, René Schmidt, Daniela Harnacke, Jörg Meyle in Clinical Oral Investigations (2018)

  13. Article

    Open Access

    Bacteraemia and fungaemia in cystic fibrosis patients with febrile pulmonary exacerbation: a prospective observational study

    Bloodstream pathogens can be identified by multiplex PCR (SeptiFast (SF)) or blood culture (BC); whether these pathogens are present in cystic fibrosis (CF) patients during febrile pulmonary exacerbations (FPE...

    Joerg Grosse-Onnebrink, Florian Stehling, Eva Tschiedel in BMC Pulmonary Medicine (2017)

  14. Article

    Effect of TH2 cytokines and interferon gamma on beat frequency of human respiratory cilia

    In asthmatic airways secondary ciliary dyskinesia contributes to impaired mucociliary clearance. To investigate underlying mechanisms, we studied the effects of cytokines associated with asthma phenotype on th...

    Joerg Grosse-Onnebrink, Claudius Werner, Niki Tomas Loges in Pediatric Research (2016)

  15. Article

    Reviewer’s comment concerning “CT morphometry of adult thoracic intervertebral discs” by Justin G. R. Fletcher et al. (Eur Spine J, 2015; doi:10.1007/s00586-015-3925-y)

    René Schmidt in European Spine Journal (2015)

  16. No Access

    Article

    Telomerase activation by genomic rearrangements in high-risk neuroblastoma

    Activation of telomere maintenance mechanisms—caused by novel somatic rearrangements of TERT, by MYCN amplification, or ATRX mutations—is a hallmark of high-risk neuroblastomas.

    Martin Peifer, Falk Hertwig, Frederik Roels, Daniel Dreidax, Moritz Gartlgruber in Nature (2015)

  17. No Access

    Article

    Adaptive designs with arbitrary dependence structure based on Fisher’s combination test

    Adaptive designs were originally developed for independent and uniformly distributed \(p\) ...

    René Schmidt, Andreas Faldum, Joachim Gerß in Statistical Methods & Applications (2015)

  18. Article

    Open Access

    Prognostic significance of clinical, histopathological, and molecular characteristics of medulloblastomas in the prospective HIT2000 multicenter clinical trial cohort

    This study aimed to prospectively evaluate clinical, histopathological and molecular variables for outcome prediction in medulloblastoma patients. Patients from the HIT2000 cooperative clinical trial were pros...

    Torsten Pietsch, Rene Schmidt, Marc Remke, Andrey Korshunov in Acta Neuropathologica (2014)

  19. No Access

    Article

    Selective thoracic fusion in AIS curves: the definition of target outcomes improves the prediction of spontaneous lumbar curve correction (SLCC)

    The decision of when to use selective thoracic fusion (STF) and the prediction of spontaneous lumbar curve correction (SLCC) remain difficult. Using a novel methodological approach, the authors yielded for a b...

    Heiko Koller, Oliver Meier, Heidrun Albrecht, Rene Schmidt in European Spine Journal (2014)

  20. No Access

    Article

    Surgical treatment of Scheuermann’s kyphosis using a combined antero-posterior strategy and pedicle screw constructs: efficacy, radiographic and clinical outcomes in 111 cases

    There is sparse literature on how best to correct Scheuermann’s kyphosis (SK). The efficacy of a combined strategy with anterior release and posterior fusion (AR/PSF) with regard to correction rate and outcome...

    Heiko Koller, Zenner Juliane, Marianne Umstaetter, Oliver Meier in European Spine Journal (2014)

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