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  1. Article

    Open Access

    Development of immunohistochemistry and in situ hybridisation for the detection of SARS-CoV and SARS-CoV-2 in formalin-fixed paraffin-embedded specimens

    The rapid emergence of SARS-CoV-2, the causative agent of COVID-19, and its dissemination globally has caused an unprecedented strain on public health. Animal models are urgently being developed for SARS-CoV-2...

    Fabian Z. X. Lean, Mart M. Lamers, Samuel P. Smith, Rebecca Shipley… in Scientific Reports (2020)

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  2. No Access

    Chapter and Conference Paper

    Asymmetric Point Spread Function Estimation and Deconvolution for Serial-Sectioning Block-Face Imaging

    Serial-sectioning block-facing (SSBF) imaging is an attractive method to overcome the depth limitations of optical imaging and slice alignment challenges of traditional serial sectioning histology. Despite the...

    Claire Walsh, Natalie Holroyd, Rebecca Shipley… in Medical Image Understanding and Analysis (2020)

  3. No Access

    Chapter and Conference Paper

    Modelling Airway Geometry as Stock Market Data Using Bayesian Changepoint Detection

    Numerous lung diseases, such as idiopathic pulmonary fibrosis (IPF), exhibit dilation of the airways. Accurate measurement of dilatation enables assessment of the progression of disease. Unfortunately the comb...

    Kin Quan, Ryutaro Tanno, Michael Duong, Arjun Nair… in Machine Learning in Medical Imaging (2019)

  4. No Access

    Article

    Computational fluid dynamics with imaging of cleared tissue and of in vivo perfusion predicts drug uptake and treatment responses in tumours

    Understanding the uptake of a drug by diseased tissue, and the drug’s subsequent spatiotemporal distribution, are central factors in the development of effective targeted therapies. However, the interaction be...

    Angela d’Esposito, Paul W. Sweeney, Morium Ali… in Nature Biomedical Engineering (2018)