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    Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia

    The adenosine A1 receptor (A1R) is a promising therapeutic target for non-opioid analgesic agents to treat neuropathic pain1,2. However, development of analgesic orthosteric A1R agonists has failed because of a l...

    Christopher J. Draper-Joyce, Rebecca Bhola, **an Wang, Apurba Bhattarai… in Nature (2021)