10 Result(s)
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Rays H.Y. Jiang
Life Sciences
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Article
Open AccessMalariaSED: a deep learning framework to decipher the regulatory contributions of noncoding variants in malaria parasites
Malaria remains one of the deadliest infectious diseases. Transcriptional regulation effects of noncoding variants in this unusual genome of malaria parasites remain elusive. We developed a sequence-based, ab ...
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Article
Open AccessA type II protein arginine methyltransferase regulates merozoite invasion in Plasmodium falciparum
Protein arginine methyltransferases (PRMTs) regulate many important cellular processes, such as transcription and RNA processing in model organisms but their functions in human malaria parasites are not elucid...
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Article
Open AccessPlasmodium vivax readiness to transmit: implication for malaria eradication
The lack of a continuous long-term in vitro culture system for Plasmodium vivax severely limits our knowledge of pathophysiology of the most widespread malaria parasite. To gain direct understanding of P. vivax h...
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Article
Open AccessAltered expression of K13 disrupts DNA replication and repair in Plasmodium falciparum
Plasmodium falciparum exhibits resistance to the artemisinin component of the frontline antimalarial treatment Artemisinin-based Combination Therapy in South East Asia. Millions of lives will be at risk if artemi...
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Article
Erratum: Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony
Nature Microbiology 2, 17017 (2017); published online 17 February 2017; corrected 6 March 2017. In the version of this Letter originally published, the in-text citations to Supplementary Table 1 and Supplement...
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Article
Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony
Plasmodium parasites, the causative agents of malaria, have evolved a unique cell division cycle in the clinically relevant asexual blood stage of infection1. DNA replication commences approximately halfway throu...
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Article
Open AccessPunctuated chromatin states regulate Plasmodium falciparum antigenic variation at the intron and 2 kb upstream regions
Understanding the regulation mechanism of var gene expression is crucial for explaining antigenic variation in Plasmodium falciparum. Recent work observed that while all var genes produce transcripts, only a few
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Protocol
Massively Parallel Sequencing Technology in Pathogenic Microbes
Next-Generation Sequencing (NGS) methods have revolutionized various aspects of genomics including transcriptome analysis. Digital expression analysis is all set to replace analog expression analysis that uses...
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Article
Nonneutral GC3 and Retroelement Codon Mimicry in Phytophthora
Phytophthora is a genus entirely comprised of destructive plant pathogens. It belongs to the Stramenopila, a unique branch of eukaryotes, phylogenetically distinct from plants, animals, or fungi....
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Article
Elicitin genes in Phytophthora infestans are clustered and interspersed with various transposon-like elements
Sequencing and annotation of a contiguous stretch of genomic DNA (112.3 kb) from the oomycete plant pathogen Phytophthora infestans revealed the order, spacing and genomic context of four members of the elicitin ...
