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Article
Setting the ventilator in acute brain injury
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Article
Mild hypocapnia and outcomes in mechanically ventilated acute brain-injured patients: another piece in the puzzle
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Article
Individualized Thresholds of Hypoxemia and Hyperoxemia and their Effect on Outcome in Acute Brain Injured Patients: A Secondary Analysis of the ENIO Study
In acute brain injury (ABI), the effects of hypoxemia as a potential cause of secondary brain damage and poor outcome are well documented, whereas the impact of hyperoxemia is unclear. The primary aim of this ...
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Open AccessCorrection: Clinical practice and effect of carbon dioxide on outcomes in mechanically ventilated acute brain-injured patients: a secondary analysis of the ENIO study
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Open AccessClinical practice and effect of carbon dioxide on outcomes in mechanically ventilated acute brain-injured patients: a secondary analysis of the ENIO study
The use of arterial partial pressure of carbon dioxide (PaCO2) as a target intervention to manage elevated intracranial pressure (ICP) and its effect on clinical outcomes remain unclear. We aimed to describe targ...
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Risk factors of extubation failure in neurocritical patients with the most impaired consciousness
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Does Differential Item Functioning Jeopardize the Comparability of Health-Related Quality of Life Assessment Between Patients and Proxies in Patients with Moderate-to-Severe Traumatic Brain Injury?
Health-related quality of life (HRQoL) is clearly recognized as a patient-important outcome in patients with traumatic brain injury (TBI). Patient-reported outcomes are therefore often used and supposed to be ...
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Open AccessMechanical ventilation in patients with acute brain injury: a systematic review with meta-analysis
To describe the potential effects of ventilatory strategies on the outcome of acute brain-injured patients undergoing invasive mechanical ventilation.
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Open AccessVentilator-associated pneumonia in neurocritically ill patients: insights from the ENIO international prospective observational study
Acute brain injured (ABI) patients are at high risk of develo** ventilator-associated pneumonia (VAP). However, incidence, risk factors and effects on outcome of VAP are not completely elucidated in this pop...
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Article
Open AccessPrevalence and risk factors of significant persistent pain symptoms after critical care illness: a prospective multicentric study
Prevalence, risk factors and medical management of persistent pain symptoms after critical care illness have not been thoroughly investigated.
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Open AccessUtilization of mechanical power and associations with clinical outcomes in brain injured patients: a secondary analysis of the extubation strategies in neuro-intensive care unit patients and associations with outcome (ENIO) trial
There is insufficient evidence to guide ventilatory targets in acute brain injury (ABI). Recent studies have shown associations between mechanical power (MP) and mortality in critical care populations. We aime...
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Article
Liberation from Mechanical Ventilation and Tracheostomy Practice in Traumatic Brain Injury
Liberating patients with severe traumatic brain injury (TBI) from mechanical ventilation is often a challenging task. These patients frequently require prolonged ventilation and have persistent alterations in ...
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Extubation in neurocritical care patients: lesson learned
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Open AccessGoal-Directed Fluid Therapy and major postoperative complications in elective craniotomy. A retrospective analysis of a before-after multicentric study
Goal-Directed Fluid Therapy (GDFT) is recommended to decrease major postoperative complications. However, data are lacking in intra-cranial neurosurgery.
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Building a better machine learning model of extubation for neurocritical care patients. Author’s reply
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Extubation in neurocritical care patients: the ENIO international prospective study
Neurocritical care patients receive prolonged invasive mechanical ventilation (IMV), but there is poor specific information in this high-risk population about the liberation strategies of invasive mechanical v...
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Open AccessAssociation between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors
Impact of in-ICU transfusion on long-term outcomes remains unknown. The purpose of this study was to assess in critical-care survivors the association between in-ICU red blood cells transfusion and 1-year mort...
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Long-term mortality and quality of life after trauma: an ancillary study from the prospective multicenter trial FROG-ICU
The long-term outcomes of intensive care unit (ICU) patients are known to be worse than those of the general population, but they are poorly known in severe trauma patients. We conducted an ancillary examinati...
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Open AccessAssessment of remifentanil for rapid sequence induction and intubation in patients at risk of pulmonary aspiration of gastric contents compared to rapid-onset paralytic agents: study protocol for a non-inferiority simple blind randomized controlled trial (the REMICRUSH study)
Rapid-onset paralytic agents are recommended to achieve muscle relaxation and facilitate tracheal intubation during rapid sequence induction in patients at risk of pulmonary aspiration of gastric contents. How...
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Open AccessDiuretics decrease fluid balance in patients on invasive mechanical ventilation: the randomized-controlled single blind, IRIHS study
Fluid overload has been associated with increased morbidity and mortality in critically ill patients. The goal of this study was to assess the efficacy and safety of a diuretic strategy to overcome positive fl...
