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    Article

    MBIP (MAP3K12 binding inhibitory protein) drives NSCLC metastasis by JNK-dependent activation of MMPs

    Metastasis is the cause for 90% of cancer-related mortalities. Identification of genetic drivers promoting dissemination of tumor cells may provide opportunities for novel therapeutic strategies. We previously...

    Joshua Kapere Ochieng, Samrat T. Kundu, Rakhee Bajaj, B. Leticia Rodriguez in Oncogene (2020)

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    Article

    IMPAD1 and KDELR2 drive invasion and metastasis by enhancing Golgi-mediated secretion

    Non-small cell lung cancer (NSCLC) is the deadliest form of cancer worldwide, due in part to its proclivity to metastasize. Identifying novel drivers of invasion and metastasis holds therapeutic potential for ...

    Rakhee Bajaj, Samrat T. Kundu, Caitlin L. Grzeskowiak, Jared J. Fradette in Oncogene (2020)

  3. Article

    Open Access

    ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer

    Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, due in part to the propensity of lung cancer to metastasize. Aberrant epithelial-to-mesenchymal transition (EMT) is a ...

    Roxsan Manshouri, Etienne Coyaud, Samrat T. Kundu, David H. Peng in Nature Communications (2019)