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Article
Neonatal inflammation and its association with asthma and obesity in late childhood among individuals born extremely preterm
Asthma and obesity are frequent outcomes among individuals born extremely preterm and are associated with decreased lifespan. Neonatal inflammation is associated with chronic neurodevelopmental disorders; howe...
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Article
Racial/ethnic differences in average CA125 and CA15.3 values and its correlates among postmenopausal women in the USA
Among healthy postmenopausal women, levels of CA125 and CA15.3 are influenced by demographic and reproductive factors, including race/ethnicity. In this study, we sought to examine the interaction between race...
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Article
The impact of maternal obesity and breast milk inflammation on developmental programming of infant growth
Little is known about how maternal obesity impacts breast milk (BM) composition and how BM composition may impact growth. We sought to determine the role of maternal body mass index (BMI) on BM inflammatory an...
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Article
Open AccessDevelopment and validation of circulating CA125 prediction models in postmenopausal women
Cancer Antigen 125 (CA125) is currently the best available ovarian cancer screening biomarker. However, CA125 has been limited by low sensitivity and specificity in part due to normal variation between individ...
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Article
Executive Dysfunction Early Postnatal Biomarkers among Children Born Extremely Preterm
We evaluated the relationship between blood levels of inflammatory and neurotrophic proteins during the first postnatal month in 692 children born before the 28th week of gestation and executive function limit...
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Article
Elevations of inflammatory proteins in neonatal blood are associated with obesity and overweight among 2-year-old children born extremely premature
Childhood obesity is associated with elevated blood concentrations of inflammation markers. It is not known to what extent inflammation precedes the development of obesity.
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Article
Both antenatal and postnatal inflammation contribute information about the risk of brain damage in extremely preterm newborns
Preterm newborns exposed to intrauterine inflammation are at an increased risk of neurodevelopmental disorders. We hypothesized that adverse outcomes are more strongly associated with a combination of antenata...
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Article
Systemic Inflammation during the First Postnatal Month and the Risk of Attention Deficit Hyperactivity Disorder Characteristics among 10 year-old Children Born Extremely Preterm
Although multiple sources link inflammation with attention difficulties, the only human study that evaluated the relationship between systemic inflammation and attention problems assessed attention at age 2 ye...
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Article
Open AccessCorrelates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort
Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women, limiting their utility for screening.
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Article
Duration of Systemic Inflammation in the First Postnatal Month Among Infants Born Before the 28th Week of Gestation
Extremely low gestational age newborns (ELGANs, <28 completed weeks of gestation) that exhibit fetal and neonatal systemic inflammatory responses are at increased risk for developmental adversity, especially i...
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Article
The relationship between TSH and systemic inflammation in extremely preterm newborns
Elevated thyrotropin (TSH) levels in critically ill extremely premature infants have been attributed to transient hypothyroidism of prematurity or non-thyroidal illness syndrome. We evaluated the hypothesis th...
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Article
Elevated blood levels of inflammation-related proteins are associated with an attention problem at age 24 mo in extremely preterm infants
Extremely preterm birth is associated with subsequent behavioral problems. We hypothesized that perinatal systemic inflammation, a risk factor for cerebral white matter injury and cognitive impairment, is asso...
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Article
Puerperal mastitis: a reproductive event of importance affecting anti-mucin antibody levels and ovarian cancer risk
Test the hypothesis that puerperal mastitis may alter immunity related to the mucin (MUC) family of glycoproteins and lower risk of ovarian cancer.
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Article
Two-hit model of brain damage in the very preterm newborn: small for gestational age and postnatal systemic inflammation
We sought to disentangle the contributions of perinatal systemic inflammation and being small for gestational age (SGA) to the occurrence of low Bayley Mental Development Indices (MDIs) at the age of 2 y.
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Article
Open AccessHomeostatic properties of Lactobacillus jensenii engineered as a live vaginal anti-HIV microbicide
Vaginal probiotics are investigated as a binary strategy for prevention of bacterial vaginosis and HIV. We applied an innovative experimental model using primary and immortalized human cervical and vaginal epi...
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Article
Relationship Between Neonatal Blood Protein Concentrations and Placenta Histologic Characteristics in Extremely Low GA Newborns
Amniotic fluid infection with chorioamnionitis is associated with increased risks of morbidity and mortality in children born prematurely. These risks depend on the presence of a fetal inflammatory response. W...
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Article
Trichomonasvirus: a new genus of protozoan viruses in the family Totiviridae
The family Totiviridae includes a number of viruses with monosegmented dsRNA genomes and isometric virions that infect either fungi or a number of medically important protozoan parasites such as Leishmania and Gi...
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Article
Mumps and ovarian cancer: modern interpretation of an historic association
Epidemiologic studies found childhood mumps might protect against ovarian cancer. To explain this association, we investigated whether mumps might engender immunity to ovarian cancer through antibodies against...
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Article
Open AccessStructural details and composition of Trichomonas vaginalis lipophosphoglycan in relevance to the epithelial immune function
Trichomonas vaginalis causes the most common non-viral sexually transmitted infection linked to increased risk of premature birth, cervical cancer and HIV. This study defines molecular do...
