15 Result(s)

Article

p140Cap inhibits β-Catenin in the breast cancer stem cell compartment instructing a protective anti-tumor immune response

The p140Cap adaptor protein is a tumor suppressor in breast cancer associated with a favorable prognosis. Here we highlight a function of p140Cap in orchestrating local and systemic tumor-extrinsic events that...

Vincenzo Salemme, Mauro Vedelago, Alessandro Sarcinella… in Nature Communications (2023)

Article

Evolution of HER2-positive mammary carcinoma: HER2 loss reveals claudin-low traits in cancer progression

HER2-positive breast cancers may lose HER2 expression in recurrences and metastases. In this work, we studied cell lines derived from two transgenic mammary tumors driven by human HER2 that showed different dy...

Veronica Giusti, Francesca Ruzzi, Lorena Landuzzi, Marianna L. Ianzano… in Oncogenesis (2021)

Article

Sparsely-connected autoencoder (SCA) for single cell RNAseq data mining

Single-cell RNA sequencing (scRNAseq) is an essential tool to investigate cellular heterogeneity. Thus, it would be of great interest being able to disclose biological information belonging to cell subpopulati...

Luca Alessandri, Francesca Cordero, Marco Beccuti… in npj Systems Biology and Applications (2021)

Article

miRNA profiles of canine cutaneous mast cell tumours with early nodal metastasis and evaluation as potential biomarkers

Cutaneous mast cell tumours (MCTs) are common skin neoplasms in dogs. MicroRNAs (miRNAs) are post-transcriptional regulators involved in several cellular processes, and they can function as tumour promoters or...

Valentina Zamarian, Roberta Ferrari, Damiano Stefanello… in Scientific Reports (2020)

Article

RNA-Seq profiling in peripheral blood mononuclear cells of amyotrophic lateral sclerosis patients and controls

Coding and long non-coding RNA (lncRNA) metabolism is now revealing its crucial role in Amyotrophic Lateral Sclerosis (ALS) pathogenesis. In this work, we present a dataset obtained via Illumina RNA-seq analys...

Susanna Zucca, Stella Gagliardi, Cecilia Pandini, Luca Diamanti… in Scientific Data (2019)

Article

Long non-coding and coding RNAs characterization in Peripheral Blood Mononuclear Cells and Spinal Cord from Amyotrophic Lateral Sclerosis patients

Alteration in RNA metabolism, concerning both coding and long non-coding RNAs (lncRNAs), may play an important role in Amyotrophic Lateral Sclerosis (ALS) pathogenesis. In this work, we performed a whole trans...

Stella Gagliardi, Susanna Zucca, Cecilia Pandini, Luca Diamanti… in Scientific Reports (2018)

Article

HashClone: a new tool to quantify the minimal residual disease in B-cell lymphoma from deep sequencing data

Mantle Cell Lymphoma (MCL) is a B cell aggressive neoplasia accounting for about the 6% of all lymphomas. The most common molecular marker of clonality in MCL, as in other B lymphoproliferative disorders, is t...

Marco Beccuti, Elisa Genuardi, Greta Romano, Luigia Monitillo… in BMC Bioinformatics (2017)

Article

Impact of Mycobacterium tuberculosis RD1-locus on human primary dendritic cell immune functions

Modern strategies to develop vaccines against Mycobacterium tuberculosis (Mtb) aim to improve the current Bacillus Calmette-Guerin (BCG) vaccine or to attenuate the virulence of Mtb vaccine candidates. In the pre...

Marilena P. Etna, Elena Giacomini, Manuela Pardini, Martina Severa… in Scientific Reports (2015)

Article

Characterization of a genetic mouse model of lung cancer: a promise to identify Non-Small Cell Lung Cancer therapeutic targets and biomarkers

Non-small cell lung cancer (NSCLC) accounts for 81% of all cases of lung cancer and they are often fatal because 60% of the patients are diagnosed at an advanced stage. Besides the need for earlier diagnosis, ...

Federica Riccardo, Maddalena Arigoni, Genny Buson, Elisa Zago… in BMC Genomics (2014)

Article

Multi-level model for the investigation of oncoantigen-driven vaccination effect

Cancer stem cell theory suggests that cancers are derived by a population of cells named Cancer Stem Cells (CSCs) that are involved in the growth and in the progression of tumors, and lead to a hierarchical st...

Francesca Cordero, Marco Beccuti, Chiara Fornari, Stefania Lanzardo… in BMC Bioinformatics (2013)

Article

Cross platform microarray analysis for robust identification of differentially expressed genes

Microarrays have been widely used for the analysis of gene expression and several commercial platforms are available. The combined use of multiple platforms can overcome the inherent biases of each approach, a...

Roberta Bosotti, Giuseppe Locatelli, Sandra Healy, Emanuela Scacheri… in BMC Bioinformatics (2007)

Article

An integrated approach of immunogenomics and bioinformatics to identify new Tumor Associated Antigens (TAA) for mammary cancer immunological prevention

Neoplastic transformation is a multistep process in which distinct gene products of specific cell regulatory pathways are involved at each stage. Identification of overexpressed genes provides an unprecedented...

Federica Cavallo, Annalisa Astolfi, Manuela Iezzi, Francesca Cordero… in BMC Bioinformatics (2005)

Article

Gene expression monitoring in hormone-responsive human breast cancer cells during estrogen-induced cell cycle progression

Luigi Cicatiello, Angelo Facchiano, Raffaele Calogero… in Nature Genetics (2001)