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  1. Article

    Open Access

    CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy

    The immunosuppressive tumor microenvironment (TME) represents a major barrier for effective immunotherapy. Tumor-associated macrophages (TAMs) are highly heterogeneous and plastic cell components of the TME wh...

    Alba Rodriguez-Garcia, Rachel C. Lynn, Mathilde Poussin… in Nature Communications (2021)

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    Article

    c-Jun overexpression in CAR T cells induces exhaustion resistance

    Chimeric antigen receptor (CAR) T cells mediate anti-tumour effects in a small subset of patients with cancer1–3, but dysfunction due to T cell exhaustion is an important barrier to progress4–6. To investigate th...

    Rachel C. Lynn, Evan W. Weber, Elena Sotillo, David Gennert, Peng Xu… in Nature (2019)