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Article
c-Jun overexpression in CAR T cells induces exhaustion resistance
Chimeric antigen receptor (CAR) T cells mediate anti-tumour effects in a small subset of patients with cancer1–3, but dysfunction due to T cell exhaustion is an important barrier to progress4–6. To investigate th...
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Article
Spatial reconstruction of single-cell gene expression data
RNA-seq data from single cells are mapped to their location in complex tissues using gene expression atlases based on in situ hybridization.
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Article
Erratum: Deconstructing transcriptional heterogeneity in pluripotent stem cells
Nature 516, 56–61 (2014); doi:10.1038/nature13920 In this Letter, owing to a production error, in Fig. 3e the sixth bar from the left was inadvertently labelled ‘Dgcr8−/− FF’ instead of ‘Dicer−/− FF’. This has...
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Article
Deconstructing transcriptional heterogeneity in pluripotent stem cells
Pluripotent stem cells (PSCs) are capable of dynamic interconversion between distinct substates; however, the regulatory circuits specifying these states and enabling transitions between them are not well unde...
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Article
Dynamic regulatory network controlling TH17 cell differentiation
Despite their importance, the molecular circuits that control the differentiation of naive T cells remain largely unknown. Recent studies that reconstructed regulatory networks in mammalian cells have focused ...
