Skip to main content

7 Result(s)

within R. Unwin Remove this filter

and

  1. Article

    Open Access

    Oxidative stress downstream of mTORC1 but not AKT causes a proliferative defect in cancer cells resistant to PI3K inhibition

    Compounds targeting phosphatidylinositol-3-kinase/mammalian target of rapamycin (PI3K/mTOR) signaling are being investigated in multiple clinical settings, but drug resistance may reduce their benefit. Compoun...

    M Dermit, P Casado, V Rajeeve, E H Wilkes, D E Foxler, H Campbell, S Critchlow… in Oncogene (2017)

    Download PDF (2098 KB) View Article

  2. Article

    Open Access

    0371. Temporal changes in systemic and renal inflammation and histology in a 72-hour rat model of faecal peritonitis

    N Arulkumaran, M Sixma, E Ceravola, R Unwin, FW Tam… in Intensive Care Medicine Experimental (2014)

    Download PDF (203 KB) View Article

  3. No Access

    Article

    Gestörter Kaliumhaushalt und Hypokaliämie

    Kalium ist das häufigste intrazelluläre Kation; etwa 98% des Kaliums liegen intrazellulär. Die Plasmaspiegel reflektieren nur 2% des Kaliums. Die Absorptionsrate entspricht etwa 70 mmol/24 h; davon werden 95% ...

    Prof. Dr. F.C. Luft, R. Unwin in Der Nephrologe (2010)

  4. No Access

    Article

    Bladder epithelial oxygen tension — a new means of monitoring regional perfusion? Preliminary study in a model of exsanguination/fluid repletion

    To assess whether monitoring of bladder epithelial oxygen tension (BEOT) would provide an indication of regional (renal) organ perfusion in an exsanguination fluid repletion animal model.

    M. Singer, C. Millar, R. Stidwill, R. Unwin in Intensive Care Medicine (1996)

  5. No Access

    Article

    The effect of acute metabolic alkalosis on bicarbonate transport along the loop of Henle. The role of active transport processes and passive paracellular backflux

    The loop of Henle (LOH) reabsorbs approximately 15% of filtered HCO 3 − via a luminal Na+-H+ exchanger and H+ATPase. During acute metabolic alkalosis (AMA) ind...

    G. Capasso, R. Unwin, F. Ciani, G. De Tommaso, M. Vinciguerra, F. Russo… in Pflügers Archiv (1994)

  6. No Access

    Article

    A comparison of the effects of the selective peripheralα 1-blocker terazosin with the selectiveβ 1-blocker atenolol on blood pressure, exercise performance and the lipid profile in mild-to-moderate essential hypertension

    The effects of six weeks of treatment with the selective peripheralα 1-adrenoceptor blocker terazosin, or the selectiveβ 1-adrenoceptor blocker atenolol on blood pressure, exercise performance and blood lipid pr...

    M. Ligueros, R. Unwin, M. R. Wilkins, J. Humphreys… in Clinical Autonomic Research (1992)

  7. No Access

    Article

    Selective α1-adrenoreceptor blockers in the treatment of hypertension: Should we be using them more?

    It has become apparent in recent years that in the treatment of essential hypertension, reduction of blood pressure alone is not sufficient to reduce significantly the morbidity and mortality from ischaemic hear...

    M. Ligueros, R. Unwin, M. Wilkins in Clinical Autonomic Research (1991)