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Article
Ammonium acylhydrazones based on 4,6-di-tert-butyl-2,3-dihydroxybenzaldehyde: synthesis, possibilities of functionalization, and evaluation of biological activity
The reaction of 4,6-di-tert-butyl-2,3-dihydroxybenzaldehyde with analogs of Girard’s reagents was used to synthesize new water-soluble ammonium acylhydrazones as individual EC=N,synN-C(O) isomers. The introductio...
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Article
Molecular and Crystal Structures of Ethyl-2-Amino-2-Bis(3,5-di-Tert-Butyl-4-Hydroxybenzyl)Ethanoate. Hydrogen Bonds in the Crystals of Sterically Hindered Phenols
Ethyl-2-amino-2-bis(3,5-di-tert-butyl-4-hydroxybenzyl)ethanoate is prepared, its molecular and crystal structures are studied. The H-bond system in the crystals of compounds containing sterically hindered phenoli...
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Article
Synthesis and antibacterial activity of fluoroquinolones with sterically hindered phenolic moieties
Fluoroquinolone antibiotics (norfloxacin, ciprofloxacin, and moxifloxacin) modified at the piperazine ring by sterically hindered phenolic moieties were synthesized and evaluated for antibacterial activity. It...
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Article
Synthesis and Antibacterial Activity of Sulfanilamides Containing Sterically Hindered Phenol Fragments
New sulfanilamide derivatives containing sterically hindered phenol fragments have been synthesized via modification of the amino group by reaction with 3,5-di-tert-butyl-4-hydroxybenzyl acetate and diazotization...
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Article
Synthesis of hybrid compounds by benzylation of acylhydrazones with 3,5-di-tert-butyl-4-hydroxybenzyl acetate
N-Benzylation of acylhydrazones of the hydroxybenzaldehyde series with 3,5-di-tert-butyl-4-hydroxybenzyl acetate was performed at room temperature in the absence of acid or base catalysts. Carboxamides do not rea...
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Article
Synthesis and Structure of Hybrid Compounds Based on Phosphoryl Acetic Acid Hydrazide, Isatin, and Sterically Hindered Phenols
In order to obtain novel biologically active substances with various types of activity, hybrid compounds based on 2-(diphenylphosphoryl)acetohydrazide, isatin, and sterically hindered phenols are synthesized. ...
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Article
Molecular and Crystal Structure of Indole and Camfora with Sterically Hindered Phenol Fragments
Molecular and crystal structure of the antioxidant 4-[3,3-bis(3,5-di-tert-butylphenyl-4- hydroxybenzyl)-3H-indole-2-ilmethylene]-2,6-di-tert-butylcyclohex-2,5-dienone (1) and (E)-3-(3,5-di-tert-butyl-4-hydroxyphe...
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Article
Synthesis and Antioxidant Activity of Sterically Hindered Phenol Derivatives of Carboxy- and Sulfobetaines
New multifunctional antioxidants based on carboxy- and sulfobetaines with sterically hindered phenol fragments were synthesized. The antioxidant capacity of the compounds determined in the reactions of their o...
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Article
Antiradical activity of benzazole-2-thiones
Reaction of benzoxazole-2-thione with 3,5-di-tert-butyl-4-hydroxybenzylacetate in methanol affords S-(3,5-di-tert-butyl-4-hydroxybenzyl)-2-mercaptobenzoxazole as the major product. Antiradical activity of S- and
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Article
Reactions of benzazole-2-thiones with 3,5-di-tert-butyl-4-hydroxybenzyl acetate
The benzylation of benzothiazole(oxazole, imidazole)-2-thiones with 3,5-di-tert-butyl-4-hydroxybenzyl acetate involves either the sulfur or nitrogen atom depending on the reaction conditions. The S- and N-benzyla...
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Article
Azo coupling of 2-hydroxymethyl-4-tert-butylphenol with sulfamoylbenzenediazonium chloride
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Article
Synthesis and antioxidant activity of modified sterically hindered phenols
Salicylaldehyde derivatives containing sterically hindered phenol fragments were synthesized. The compounds obtained are capable to offer protection against UV radiation.
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Article
Synthesis of Modified Sterically Hindered Phenols and Investigation of Their Ability to Protect Bacterial DNA Against UVB Damage
New derivatives of sterically hindered phenols were obtained. Their DNA-protective activity under UV irradiation was studied. The experimental results showed that the investigated compounds protected genetic m...
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Article
Reaction of alkyl splitting of 4-acetylamino-N-(3,5-di-tert-butyl-4-hydroxybenzyl)-benzenesulfonamide
Alkyl splitting of 4-acetylamino-N-(3,5-di-tert-butyl-4-hydroxybenzyl)benzenesulfonamide with alkali solution has been discovered, the reaction being uncommon for amides. The driving force of the process is the t...
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Article
Antioxidant activity of isatin acylhydrazones with sterically hindered phenol fragments
Sterically hindered phenolic isatin acylhydrazones were found to possess high antioxidant activity in model reaction with a free chromogen-radical 2,2-diphenyl-1-picrylhydrazyl (DPPH).
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Article
Synthesis, Toxicity, and Antituberculosis Activity of Isoniazid Derivatives Containing Sterically Hindered Phenols
The toxicity and tuberculostatic activity of new isoniazid derivatives containing sterically hindered phenols were investigated. The investigated isoniazid derivatives exhibited lower activity and toxicity tha...
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Article
Synthesis of sterically hindered phenol-containing phosphorylated isatin derivatives
Addition of isatin to the exocyclic double bond of dimethyl (3,5-di-tert-butyl-4-oxocyclohexa-2,5-dienylidene)methylphosphonate gave dimethyl (3,5-di-tert-butyl-4-hydroxyphenyl)(2,3-dioxo-2,3-dihydro-1H-indol-1-y...
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Article
A cobalt(ii) acetate complex with 1-(3,5-di-tert-butyl-4-hydroxybenzyl)-1H-indole-2,3-dione 3-thiosemicarbazone: synthesis and structure
A complex of CoII with 1-(3,5-di-tert-butyl-4-hydroxybenzyl)-1H-indole-2,3-dione 3-thiosemicarbazone was obtained and identified by X-ray diffraction, IR and Raman spectroscopy, and quantum chemical calculations....
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Article
Isatin acylhydrazones with sterically hindered phenolic fragments: synthesis and structures
Isatin acylhydrazones with sterically hindered phenolic fragments were obtained. Their structures were determined using 1D and 2D 1H and 13C NMR spectroscopy and X-ray diffraction. The products synthesized by ...
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Article
Synthesis of sterically hindered phenolic compounds from indole and its derivatives
Reactions of 3,5-di-tert-butyl-4-hydroxybenzyl acetate with indole and its derivatives gave a series of sterically hindered phenolic compounds having various functional groups. The products are potentially capabl...
