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Article
Open AccessReal-life data of Pasireotide LAR in acromegaly: a long-term follow-up
Pasireotide LAR (PAS-LAR) was released in Italy in 2017 to treat acromegaly patients resistant to SRLs (Somatostatin Receptors Ligands). The long-term follow-up data of PAS-LAR therapy in Italy are limited. Th...
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Article
Open AccessHuman protective response induced by meningococcus B vaccine is mediated by the synergy of multiple bactericidal epitopes
4CMenB is the first broad coverage vaccine for the prevention of invasive meningococcal disease caused by serogroup B strains. To gain a comprehensive picture of the antibody response induced upon 4CMenB vacci...
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Article
Screening della sindrome di Cushing in pazienti ambulatoriali con diabete mellito di tipo 2: risultati di uno studio prospettico multicentrico in Italia
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Article
Levodopa therapy reduces DNA damage in peripheral blood cells of patients with Parkinson’s disease
Oxidative stress seems to play a major role in the pathogenesis of neurodegeneration. In Parkinson’s disease (PD) patients, the dopaminergic neurons are subjected to oxidative stress resulting from reduced lev...
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Article
Perioperative Cortisol can predict hypothalamus-pituitary-adrenal status in clinically non-functioning pituitary adenomas
Background: Peri-operative steroids are administered routinely to patients with pituitary adenoma undergoing transsphenoidal adenomectomy (TSA). Aim: To evaluate hypothalamic-pituitary-ad...
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Article
Efficacy of the new long-acting formulation of lanreotide (Lanreotide Autogel) in somatostatin analogue-naive patients with acromegaly
Objective: To evaluate efficacy and safety of lanreotide autogel (ATG) 120 mg injections every 4–8 weeks in somatostatin analogue-na"ive patients with acromegaly. Design: Open, non-compar...
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Article
Somatostatin analogs and gallstones: A retrospective survey on a large series of acromegalic patients
Context: Development of gallstones (GS) is reported during the use of somatostatin analogs (SA) that are at present the mainstay for the medical treatment of acromegaly. Objective: To rev...
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Article
Pegvisomant in acromegaly: Why, when, how
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Article
First-line therapy of acromegaly: A statement of the A.L.I.C.E. (Acromegaly primary medical treatment Learning and Improvement with Continuous Medical Education) Study Group
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Article
La risposta agli analoghi della somatostatina migliora dopo resezione parziale del tumore ipofisario GH-secernente nei pazienti con acromegalia
L’intervento chirurgico di adenomectomia rappresenta uno dei capisaldi del trattamento dell’acromegalia; peraltro, la sua efficacia nei tumori ipofisari GH-secernenti di grosse dimensioni e con spiccate caratt...
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Article
Cabergoline-induced CSF rhinorrhea in patients with macroprolactinoma. Report of three cases
Three cases of cerebrospinal fluid (CSF) leak, in subjects with an invasive macroprolactinoma under treatment with cabergoline (CAB), are reported. The patients underwent surgical treatment by means of an endo...
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Article
Scintigraphic imaging of pituitary adenomas: An in vivo evaluation of somatostatin receptors
We have performed pituitary scintigraphy with the somatostatin (SS) analog pentetreotidean by (111In-P) in patients with GH-secreting adenoma or with “clinically non functioning” adenoma (NFA) to evaluate the pre...
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Chapter
Endocrine Tests and Hormonal Therapy in Craniopharyngioma
The hypothalamus exerts control over the anterior pituitary gland and synthesizes hormones of the posterior pituitary: vasopressin and oxytocin are synthesized in the hypothalamic-supraoptic and paraventricula...
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Article
Doxorubicine for acromegaly: a case report
We report the case of an acromegalic woman, aged 35 years, with a huge GH-secreting tumor, repeatedly treated with neurosurgery and radiotherapy, not responsive to bromocriptine (Br) and octreotide (SMS), whos...
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Chapter
Chronic Complications in Diabetic Hemodialyzed Patients
We studied the chronic complications in 12 type I diabetic uremic patients treated by hemodialysis. After a two-year-follow-up, we observed a relative stability of retinopathy and a general progression of card...
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Article
Prolactin response to growth hormone-releasing hormone during chronic thyrotropin-releasing hormone infusion in the treatment of amyotrophic lateral sclerosis
In six patients suffering from amyotrophic lateral sclerosis we evaluated changes of T4, T3, TSH, PRL, and GH during treatment by continuous iv infusion of TRH for at least 15 days. No clinical improvement was...
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Article
Resistance to a long-acting somatostatin analog (SMS 201-995) reversed by surgery in acromegaly
A 42-year-old woman had acromegaly and a large macroadenoma with supra- and parasellar extension. Her GH levels (median 85 ng/ml, range 63–170 ng/ml) were not responsive to TRH (200 μg iv), GHRH (100 μg iv) an...
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Chapter and Conference Paper
Medical treatment of acromegaly — Dopa-minergic agonists and long-acting somatostatin
The medical treatment of acromegaly derives its values from the fact that neurosurgey and radiation therapy may be, in this disease, frequently unsuccessful. Indeed, the frequency with which neurosurgery cures...
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Chapter and Conference Paper
Medical Treatment of Acromegaly. Dopaminergic Agonists and Long-Acting Somatostatin
The medical treatment of acromegaly is of value because neurosurgery and Rx therapy may be unsuccessful in this disease.
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Article
Effectiveness.of the dopamine agonist lisuride in the treatment of acromegaly and pathological hyperprolactinemic states
We have studied the effects of the chronic administration of the dopamine agonist lisuride (L) in 21 acromegalics (group 1) and in 25 patients with pathological hyperprolactinemia (group 2). Before starting th...
