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  1. Article

    Open Access

    A phase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumours

    Poly adenosine diphosphate (ADP)-ribose polymerase (PARP) is essential in cellular processing of DNA damage via the base excision repair pathway (BER). The PARP inhibition can be directly cytotoxic to tumour c...

    O A Khan, M Gore, P Lorigan, J Stone, A Greystoke, W Burke… in British Journal of Cancer (2011)

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  2. Article

    Open Access

    Phase III randomised trial of doxorubicin-based chemotherapy compared with platinum-based chemotherapy in small-cell lung cancer

    This randomised trial compared platinum-based to anthracycline-based chemotherapy in patients with small-cell lung cancer (limited or extensive stage) and ⩽2 adverse prognostic factors. Patients were randomise...

    S Baka, R Califano, R Ferraldeschi, L Aschroft, N Thatcher… in British Journal of Cancer (2008)

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